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Uppsala University Uppsala University Department of Medical Biochemistry and Microbiology
Department of Medical Biochemistry and Microbiology
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Uppsala University Department of Medical ... Research groups Infection and immunity Sandegren Linus Publications
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  • Research areas
  • Research groups
  • Professor Emeriti
  • Publications at IMBIM
  • Infrastructure
  • Education
  • Seminars
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  • INTERNAL INFO

Publications

  • Genomically diverse carbapenem resistant Enterobacteriaceae fromwild birds provide insight into global patterns of spatiotemporal dissemination.

    Ahlstrom, C., Woksepp, H., Sandegren, L., Mohsin, M., Hasan, B. et al. (2022). Science of the Total Environment, . vol. 824 DOI
  • Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48-and NDM-Producing Escherichia coli and Klebsiella pneumoniae.

    Allander, L., Vickberg, K., Lagerbäck, P., Sandegren, L., Tängdén, T. (2022). Antibiotics, . vol. 11 DOI
  • A simple cut and stretch assay to detect antimicrobial resistance genes on bacterial plasmids by single-molecule fluorescence microscopy.

    Goyal, G., Ekedahl, E., Nyblom, M., Krog, J., Fröbrant, E. et al. (2022). Scientific Reports, . vol. 12 DOI
  • Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters.

    Palica, K., Vorácová, M., Skagseth, S., Andersson Rasmussen, A., Allander, L. et al. (2022). ACS Omega, . vol. 7, ss. 4550-4562 DOI
  • Evolutionary Trajectories toward High-Level β-Lactam/β-Lactamase Inhibitor Resistance in the Presence of Multiple β-Lactamases.

    Rajer, F., Allander, L., Karlsson, P., Sandegren, L. (2022). Antimicrobial Agents and Chemotherapy, . vol. 66 DOI
  • The Role of Antibiotic Resistance Genes in the Fitness Cost of Multiresistance Plasmids.

    Rajer, F., Sandegren, L. (2022). mBio, . vol. 13 DOI
  • Naked-eye detection of antibiotic resistance gene sul1 based on aggregation of magnetic nanoparticles and DNA amplification products.

    Sánchez Martín, D., Wrande, M., Sandegren, L., Zardán Gómez de la Torre, T. (2022). Biosensors and Bioelectronics: X, . vol. 12 DOI
  • Modular 3D-Printed Peg Biofilm Device for Flexible Setup of Surface-Related Biofilm Studies.

    Zaborskyte, G., Wistrand-Yuen, E., Hjort, K., Andersson, D., Sandegren, L. (2022). Frontiers in Cellular and Infection Microbiology, . vol. 11 DOI
  • Selection of Resistant Bacteria in Mallards Exposed to Subinhibitory Concentrations of Ciprofloxacin in Their Water Environment.

    Atterby, C., Nykvist, M., Lustig, U., Andersson, D., Järhult, J. et al. (2021). Antimicrobial Agents and Chemotherapy, . vol. 65 DOI
  • Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach.

    Dvirnas, A., Stewart, C., Müller, V., Bikkarolla, S., Frykholm, K. et al. (2021). PLOS ONE, . vol. 16, ss. e0259670-e0259670 DOI
  • A Parallelized Nanofluidic Device for High-Throughput Optical DNA Mapping of Bacterial Plasmids.

    KK, S., Lin, Y., Sewunet, T., Wrande, M., Sandegren, L. et al. (2021). Micromachines, vol. 12 DOI
  • Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.

    Hjort, K., Jurén, P., Toro, J., Hoffner, S., Andersson, D. et al. (2020). Journal of Infectious Diseases, . vol. 225, ss. 1011-1020 DOI
  • Cultivation-Free Typing of Bacteria Using Optical DNA Mapping.

    Muller, V., Nyblom, M., Johnning, A., Wrande, M., Dvirnas, A. et al. (2020). ACS INFECTIOUS DISEASES, vol. 6, ss. 1076-1084 DOI
  • Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments.

    Olsson, A., Wistrand-Yuen, P., Nielsen, E., Friberg, L., Sandegren, L. et al. (2020). Antimicrobial Agents and Chemotherapy, . vol. 64 DOI
  • Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak.

    Bikkarolla, S., Nordberg, V., Rajer, F., Mueller, V., Kabir, M. et al. (2019). mBio, . vol. 10 DOI
  • Dynamics of Resistance Plasmids in Extended-Spectrum-beta-Lactamase-Producing Enterobacteriaceae during Postinfection Colonization.

    Brolund, A., Rajer, F., Giske, C., Melefors, Ö., Titelman, E. et al. (2019). Antimicrobial Agents and Chemotherapy, . vol. 63 DOI
  • Genome and plasmid diversity of Extended-Spectrum beta-Lactamase-producing Escherichia coli ST131-tracking phylogenetic trajectories with Bayesian inference.

    Ny, S., Sandegren, L., Salemi, M., Giske, C. (2019). Scientific Reports, . vol. 9 DOI
  • Low sub-minimal inhibitory concentrations of antibiotics generate new types of resistance.

    Sandegren, L. (2019). Sustainable Chemistry and Pharmacy, vol. 11 11, ss. 46 46-48 48 DOI
  • Facilitated sequence assembly using densely labeled optical DNA barcodes: A combinatorial auction approach.

    Dvirnas, A., Pichler, C., Stewart, C., Quaderi, S., Nyberg, L. et al. (2018). PLOS ONE, vol. 13 DOI
  • Long-term carriage and rapid transmission of extended spectrum beta-lactamase-producing E. coli within a flock of Mallards in the absence of antibiotic selection.

    Sandegren, L., Stedt, J., Lustig, U., Bonnedahl, J., Andersson, D. et al. (2018). Environmental Microbiology Reports, vol. 10, ss. 576-582 DOI
  • A bla(OXA-181)-harbouring multi-resistant ST147 Klebsiella pneumoniae isolate from Pakistan that represent an intermediate stage towards pan-drug resistance.

    Nahid, F., Zahra, R., Sandegren, L. (2017). PLOS ONE, . vol. 12 DOI
  • Combinations of mutations in envZ, ftsI, mrdA, acrB and acrR can cause high-level carbapenem resistance in Escherichia coli.

    Adler, M., Anjum, M., Andersson, D., Sandegren, L. (2016). Journal of Antimicrobial Chemotherapy, vol. 71, ss. 1188-1198 DOI
  • Characterization of ESBL disseminating plasmids.

    Brolund, A., Sandegren, L. (2016). INFECTIOUS DISEASES, vol. 48, ss. 18-25 DOI
  • Fitness of Escherichia coli mutants with reduced susceptibility to tigecycline.

    Linkevicius, M., Anderssen, J., Sandegren, L., Andersson, D. (2016). Journal of Antimicrobial Chemotherapy, vol. 71, ss. 1307-1313 DOI
  • Potential of tetracycline resistance proteins to evolve tigecycline resistance.

    Linkevicius, M., Sandegren, L., Andersson, D. (2016). Antimicrobial Agents and Chemotherapy, vol. 60, ss. 789-796 DOI
  • Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping.

    Mueller, V., Rajer, F., Frykholm, K., Nyberg, L., Quaderi, S. et al. (2016). Scientific Reports, vol. 6 DOI
  • Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules.

    Nyberg, L., Quaderi, S., Emilsson, G., Karami, N., Lagerstedt, E. et al. (2016). Scientific Reports, vol. 6 DOI
  • A pharmacokinetic-pharmacodynamic model characterizing the emergence of resistant Escherichia coli subpopulations during ertapenem exposure.

    Ungphakorn, W., Tängdén, T., Sandegren, L., Nielsen, E. (2016). Journal of Antimicrobial Chemotherapy, vol. 71, ss. 2521-2533 DOI
  • Fast size-determination of intact bacterial plasmids using nanofluidic channels.

    Frykholm, K., Nyberg, L., Lagerstedt, E., Noble, C., Fritzsche, J. et al. (2015). Lab on a Chip, vol. 15, ss. 2739-2743 DOI
  • High Fitness Costs and Instability of Gene Duplications Reduce Rates of Evolution of New Genes by Duplication-Divergence Mechanisms.

    Adler, M., Anjum, M., Berg, O., Andersson, D., Sandegren, L. (2014). Molecular biology and evolution, vol. 31, ss. 1526-1535 DOI
  • Selection of a multidrug resistance plasmid by sublethal levels of antibiotics and heavy metals.

    Gullberg, E., Albrecht, L., Karlsson, C., Sandegren, L., Andersson, D. (2014). mBio, vol. 5, ss. e01918-14- DOI
  • The Gull (Chroicocephalus brunnicephalus) as an Environmental Bioindicator and Reservoir for Antibiotic Resistance on the Coastlines of the Bay of Bengal.

    Hasan, B., Melhus, Å., Sandegren, L., Alam, M., Olsen, B. (2014). Microbial Drug Resistance, vol. 20, ss. 466-471 DOI
  • Time lapse investigation of antibiotic susceptibility using a microfluidic linear gradient 3D culture device.

    Hou, Z., An, Y., Hjort, K., Hjort, K., Sandegren, L. et al. (2014). Lab on a Chip, vol. 14, ss. 3409-3418 DOI
  • Selection of Orphan Rhs Toxin Expression in Evolved Salmonella enterica Serovar Typhimurium.

    Koskiniemi, S., Garza-Sanchez, F., Sandegren, L., Webb, J., Braaten, B. et al. (2014). PLOS Genetics, vol. 10, ss. e1004255- DOI
  • Selection of antibiotic resistance at very low antibiotic concentrations.

    Sandegren, L. (2014). Upsala Journal of Medical Sciences, vol. 119, ss. 103-107 DOI
  • Silver resistance genes are overrepresented among Escherichia coli isolates with CTX-M production.

    Sütterlin, S., Edquist, P., Sandegren, L., Adler, M., Tängdén, T. et al. (2014). Applied and Environmental Microbiology, vol. 80, ss. 6863-6869 DOI
  • Influence of acquired β-lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli.

    Adler, M., Anjum, M., Andersson, D., Sandegren, L. (2013). Journal of Antimicrobial Chemotherapy, vol. 68, ss. 51-59 DOI
  • Plasmidome-Analysis of ESBL-Producing Escherichia coli Using Conventional Typing and High-Throughput Sequencing.

    Brolund, A., Franzen, O., Melefors, O., Tegmark-Wisell, K., Sandegren, L. (2013). PLOS ONE, vol. 8, ss. e65793- DOI
  • Pathoadaptive Mutations in Salmonella enterica Isolated after Serial Passage in Mice.

    Koskiniemi, S., Gibbons, H., Sandegren, L., Anwar, N., Ouellette, G. et al. (2013). PLOS ONE, vol. 8, ss. e70147- DOI
  • Mechanisms and fitness costs of tigecycline resistance in Escherichia coli.

    Linkevicius, M., Sandegren, L., Andersson, D. (2013). Journal of Antimicrobial Chemotherapy, vol. 68, ss. 2809-2819 DOI
  • Frequent emergence of porin-deficient subpopulations with reduced carbapenem susceptibility in ESBL-producing Escherichia coli during exposure to ertapenem in an in vitro pharmacokinetic model.

    Tängdén, T., Adler, M., Cars, O., Sandegren, L., Löwdin, E. (2013). Journal of Antimicrobial Chemotherapy, vol. 68, ss. 1319-1326 DOI
  • Antimicrobial Drug-Resistant Escherichia coli in Wild Birds and Free-range Poultry, Bangladesh.

    Hasan, B., Sandegren, L., Melhus, Å., Drobni, M., Hernandez, J. et al. (2012). Emerging Infectious Diseases, vol. 18, ss. 2055-2058 DOI
  • Transfer of an Escherichia coli ST131 multiresistance cassette has created a Klebsiella pneumoniae-specific plasmid associated with a major nosocomial outbreak.

    Sandegren, L., Linkevicius, M., Lytsy, B., Åsa, M., Andersson, D. (2012). Journal of Antimicrobial Chemotherapy, vol. 67, ss. 74-83 DOI
  • Selection of Resistant Bacteria at Very Low Antibiotic Concentrations.

    Gullberg, E., Cao, S., Berg, O., Ilbäck, C., Sandegren, L. et al. (2011). PLoS pathogens, vol. 7, ss. e1002158- DOI
  • Genomic Stability over 9 Years of an Isoniazid Resistant Mycobacterium tuberculosis Outbreak Strain in Sweden.

    Sandegren, L., Groenheit, R., Koivula, T., Ghebremichael, S., Advani, A. et al. (2011). PLoS ONE, vol. 6, ss. e16647- DOI
  • Bacterial gene amplification: implications for the evolution of antibiotic resistance.

    Sandegren, L., Andersson, D. (2009). Nature Reviews Microbiology, vol. 7, ss. 578-588 DOI
  • The first major extended-spectrum beta-lactamase outbreak in Scandinavia was caused by clonal spread of a multiresistant Klebsiella pneumoniae producing CTX-M-15.

    Lytsy, B., Sandegren, L., Tano, E., Torell, E., Andersson, D. et al. (2008). Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), vol. 116, ss. 302-8 DOI
  • Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli.

    Sandegren, L., Lindqvist, A., Kahlmeter, G., Andersson, D. (2008). Journal of Antimicrobial Chemotherapy, vol. 62, ss. 495-503 DOI
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