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Uppsala University Uppsala University Department of Medical Biochemistry and Microbiology
Department of Medical Biochemistry and Microbiology
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Uppsala University Department of Medical ... Research groups Infection and immunity Akusjärvi Göran Publications
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  • Research areas
  • Research groups
  • Publications at IMBIM
  • Infrastructure
  • Professor Emeriti
  • Education
  • Seminars
  • Contact
  • INTERNAL INFO

Publications

  • Ixovex-1, a novel oncolytic E1B-mutated adenovirus.

    Anwar, M., Arendt, M., Ramachandran, M., Carlsson, A., Essand, M. et al. (2022). Cancer Gene Therapy, . vol. 29, ss. 1628-1635 DOI
  • ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression.

    Darweesh, M., Younis, S., Hajikhezri, Z., Ali, A., Jin, C. et al. (2022). Frontiers in Immunology, . vol. 13 DOI
  • The Human Adenovirus 2 Transcriptome: An Amazing Complexity of Alternatively Spliced mRNAs.

    Westergren Jakobsson, A., Segerman, B., Wallerman, O., Bergström Lind, S., Zhao, H. et al. (2021). Journal of Virology, vol. 95 DOI
  • Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections.

    Hajikhezri, Z., Darweesh, M., Akusjärvi, G., Punga, T. (2020). Viruses, vol. 12 DOI
  • Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs.

    Punga, T., Darweesh, M., Akusjärvi, G. (2020). Viruses, . vol. 12 DOI
  • Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation.

    Darweesh, M., Kamel, W., Gavrilin, M., Akusjärvi, G., Svensson, C. (2019). Frontiers in Immunology, vol. 10 DOI
  • Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth.

    Younis, S., Kamel, W., Falkeborn, T., Wang, H., Yu, D. et al. (2018). Proceedings of the National Academy of Sciences of the United States of America, vol. 115, ss. E3808-E3816 DOI
  • Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes.

    Assadian, F., Kamel, W., Laurell, G., Svensson, C., Punga, T. et al. (2017). PLOS ONE, . vol. 12 DOI
  • An Ago2-associated capped transcriptional start site small RNA suppresses adenovirus DNA replication.

    Kamel, W., Akusjärvi, G. (2017). RNA, vol. 23, ss. 1700-1711 DOI
  • The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding.

    Lan, S., Kamel, W., Punga, T., Akusjärvi, G. (2017). Nucleic Acids Research, vol. 45, ss. 1731-1742 DOI
  • Distribution and Molecular Characterization of Human Adenovirus and Epstein-Barr Virus Infections in Tonsillar Lymphocytes Isolated from Patients Diagnosed with Tonsillar Diseases.

    Assadian, F., Sandström, K., Bondeson, K., Laurell, G., Lidian, A. et al. (2016). PLOS ONE, vol. 11 DOI
  • HAdV-2-suppressed growth of SV40 T antigen-transformed mouse mammary epithelial cell-induced tumours in SCID mice.

    Wu, C., Cao, X., Yu, D., Huijbers, E., Essand, M. et al. (2016). Virology, vol. 489, ss. 44-50 DOI
  • Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils.

    Assadian, F., Sandström, K., Laurell, G., Svensson, C., Akusjärvi, G. et al. (2015). Journal of Visualized Experiments, vol. 105 DOI
  • Regulation of Human Adenovirus Alternative RNA Splicing by the Adenoviral L4-33K and L4-22K Proteins.

    Biasiotto, R., Akusjärvi, G. (2015). International Journal of Molecular Sciences, vol. 16, ss. 2893-2912 DOI
  • Complementation of the human adenovirus type 5 VA RNAI defect by the Vaccinia virus E3L protein and serotype-specific VA RNAIs.

    Inturi, R., Kamel, W., Akusjärvi, G., Punga, T. (2015). Virology, vol. 485, ss. 25-35 DOI
  • A suppressive effect of Sp1 recruitment to the first leader 5' splice site region on L4-22K-mediated activation of the adenovirus major late promoter.

    Lan, S., Östberg, S., Punga, T., Akusjärvi, G. (2015). Virus Research, vol. 210, ss. 133-140 DOI
  • Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells.

    Pickl, J., Kamel, W., Ciftci, S., Punga, T., Akusjärvi, G. (2015). FEBS Letters, vol. 589, ss. 1383-1388 DOI
  • Poor growth of human adenovirus-12 compared to adenovirus-2 correlates with a failure to impair PKR activation during the late phase of infection.

    Wu, C., Bai, L., Li, Z., Samuel, C., Akusjärvi, G. et al. (2015). Virology, vol. 475, ss. 120-128 DOI
  • Small RNA Sequence Analysis of Adenovirus VA RNA-Derived MiRNAs Reveals an Unexpected Serotype-Specific Difference in Structure and Abundance.

    Kamel, W., Segerman, B., Punga, T., Akusjärvi, G. (2014). PLOS ONE, vol. 9, ss. e105746- DOI
  • Regulation of adenovirus alternative RNA splicing by PKA, DNA-PK, PP2A and SR proteins.

    Kvissel, A., Törmänen Persson, H., Aksaas, A., Akusjärvi, G., Skålheff, B. (2014). I iConcept Press (red.) Virology II: Advanced Issues .
  • The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells.

    Kamel, W., Segerman, B., Oberg, D., Punga, T., Akusjärvi, G. (2013). Nucleic Acids Research, vol. 41, ss. 4802-4812 DOI
  • Old and new functions for the adenovirus virus-associated RNAs.

    Punga, T., Kamel, W., Akusjarvi, G. (2013). Future Virology, vol. 8, ss. 343-356 DOI
  • A mouse mammary epithelial cell line permissive for highly efficient human adenovirus growth.

    Wu, C., Öberg, D., Rashid, A., Gupta, R., Mignardi, M. et al. (2013). Virology, vol. 435, ss. 363-371 DOI
  • Two Cellular Protein Kinases, DNA-PK and PKA, Phosphorylate the Adenoviral L4-33K Protein and Have Opposite Effects on L1 Alternative RNA Splicing.

    Törmänen Persson, H., Aksaas, A., Kvissel, A., Punga, T., Engström, Å. et al. (2012). PLOS ONE, ss. e31871- DOI
  • Serine 192 in the tiny RS repeat of the adenoviral L4-33K splicing enhancer protein is essential for function and reorganization of the protein to the periphery of viral replication centers.

    Östberg, S., Törmänen Persson, H., Akusjärvi, G. (2012). Virology, vol. 433, ss. 273-281 DOI
  • Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein..

    Aksaas, A., Eikvar, S., Akusjärvi, G., Skålhegg, B., Kvissel, A. (2011). Genes & cancer, vol. 2, ss. 841-851 DOI
  • Using the whole-genome sequence to characterize and name human adenoviruses.

    Seto, D., Chodosh, J., Brister, J., Jones, M., Akusjärvi, G. (2011). Journal of Virology, vol. 85, ss. 5701-5702 DOI
  • Characterization of RISC-associated adenoviral small RNAs.

    Xu, N., Akusjärvi, G. (2011). Methods in molecular biology (Clifton, N.J.), vol. 721, ss. 183-198 DOI
  • Adenovirus L4-22K stimulates major late transcription by a mechanism requiring the intragenic late-specific transcription factor-binding site.

    Backström, E., Kaufmann, K., Lan, X., Akusjärvi, G. (2010). Virus Research, vol. 151, ss. 220-228 DOI
  • Single molecule analysis of combinatorial splicing.

    Conze, T., Göransson, J., Razzaghian, H., Ericsson, O., Öberg, D. et al. (2010). Nucleic Acids Research, vol. 38, ss. e163- DOI
  • Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity Engendered by a Kinase-Inactive Human HER2 Adenovirus-Based Vaccination Mediates Resistance to Breast Tumors.

    Triulzi, C., Vertuani, S., Curcio, C., Antognoli, A., Seibt, J. et al. (2010). Cancer Research, vol. 70, ss. 7431-7441 DOI
  • Adenovirus E4orf4 induces HPV-16 late L1 mRNA production.

    Somberg, M., Rush, M., Fay, J., Ryan, F., Lambkin, H. et al. (2009). Virology, vol. 383, ss. 279-290 DOI
  • The 5′-end heterogeneity of adenovirus virus-associated RNAI contributes to the asymmetric guide strand incorporation into the RNA-induced silencing complex.

    Xu, N., Gkountela, S., Saeed, K., Akusjärvi, G. (2009). Nucleic Acids Research, vol. 37, ss. 6950-6959 DOI
  • Temporal regulation of adenovirus major late alternative RNA splicing.

    Akusjärvi, G. (2008). Frontiers in Bioscience, vol. 13, ss. 5006-5015 DOI
  • Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion.

    Dyachok, O., Idevall-Hagren, O., Sågetorp, J., Tian, G., Wuttke, A. et al. (2008). Cell Metabolism, . vol. 8, ss. 26-37 DOI
  • Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression.

    Sol, E., Sargsyan, E., Akusjärvi, G., Bergsten, P. (2008). Biochemical and Biophysical Research Communications - BBRC, vol. 375, ss. 517-521 DOI
  • Messenger RNA in Eukaryotes.

    Akusjärvi, G., Kreivi, J., Petersen-Mahrt, S. (2007). I Encyclopedia of Life Sciences, Chichester: John Wiley. ss. 1-8 DOI
  • In vitro methods to study RNA interference during an adenovirus infection.

    Andersson, G., Xu, N., Akusjärvi, G. (2007). I Adenovirus Methods and Protocols: Volume 2: Ad Proteins, RNA Lifecycle, Host Interactions, and Phylogenetics, . ss. 47-61
  • Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing.

    Kvissel, A., Ørstavik, S., Eikvar, S., Brede, G., Jahnsen, T. et al. (2007). Experimental Cell Research, vol. 313, ss. 2795-2809 DOI
  • Preparation of Soluble Extracts From Adenovirus-Infected Cells for Studies of RNA Spicing.

    Mühlemann, O., Akusjärvi, G. (2007). I Adenovirus Methods and Protocols, . ss. 33-46
  • Preparation of soluble extracts from adenovirus-infected cells for studies of RNA-splicing.

    Mühlemann, O., Akusjärvi, G. (2007). I Wold, William S. M. & Tollefson, Ann E. (red.) Adenovirus Methods and Protocols, . ss. 33-46 DOI
  • Adenovirus virus-associated RNAII-derived small RNAs are efficiently incorporated into the RNA-induced silencing complex and associate with polyribosomes.

    Xu, N., Segerman, B., Zhou, X., Akusjärvi, G. (2007). Journal of Virology, vol. 81, ss. 10540-10549 DOI
  • Binary AdEasy vector systems designed for Tet-ON or Tet-OFF regulated control of transgene expression..

    Berenjian, S., Akusjärvi, G. (2006). Virus Res, vol. 115, ss. 16-23
  • Binary AdEasy Vector systems designed for Tet-ON or Tet-OFF regulated control of transgene expression.

    Berenjian, S., Akusjärvi, G. (2006). Virus research, vol. 115, ss. 16-23
  • L4-33K, an adenovirus-encoded alternative RNA splicing factor.

    Törmänen, H., Backström, E., Carlsson, A., Akusjärvi, G. (2006). Journal of Biological Chemistry, vol. 281, ss. 36510-36517 DOI
  • Cellular splicing and transcription regulatory protein p32 represses adenovirus major late transcription and causes hyperphosphorylation of RNA polymerase II.

    Öhrmalm, C., Akusjärvi, G. (2006). Journal of Virology, vol. 80, ss. 5010-5020 DOI
  • Suppression of RNA interference by adenovirus virus-associated RNA.

    Andersson, M., Haasnoot, P., Xu, N., Berenjian, S., Berkhout, B. et al. (2005). Journal of Virology, vol. 79, ss. 9556-65 DOI
  • Adenoviral-mediated transduction of human pancreatic islets: importance of adenoviral genome for cell viability and association with a deficient antiviral response.

    Barbu, A., Akusjärvi, G., Welsh, N. (2005). Endocrinology, vol. 146, ss. 2406-2414 DOI
  • Substrate-dependent differences in U2AF requirement for splicing in adenovirus-infected cell extracts..

    Lützelberger, M., Backström, E., Akusjärvi, G. (2005). J Biol Chem, vol. 280, ss. 25478-84
  • The second RNA-binding domain of the human splicing factor ASF/SF2 is the critical domain controlling adenovirus E1A alternative 5'-splice site selection..

    Dauksaite, V., Akusjärvi, G. (2004). Biochem J, vol. 381, ss. 343-50
  • Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins.

    Lee, T., Lawrence, F., Dauksaite, V., Akusjärvi, G., Blair, G. et al. (2004). Journal of General Virology, vol. 85, ss. 185-196 DOI
  • Remodelling of the host cell RNA splicing machinery during an adenovirusinfection.

    Akusjärvi, G., Stevenin, J. (2003). Current Topics in Microbiology and Immunology, vol. 272, ss. 253-286
  • Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters..

    Punga, T., Akusjärvi, G. (2003). FEBS Letters, vol. 552, ss. 214-218
  • Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters.

    Punga, T., Akusjärvi, G. (2003). FEBS Letters, vol. 552, ss. 214-218 DOI
  • Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression.

    Barbu, A., Akusjärvi, G., Welsh, N. (2002). Molecular Medicine, vol. 8, ss. 733-741
  • Human Splicing Factor ASF/SF2 Encodes for a Repressor Domain Required for Its Inhibitory Activity on Pre-mRNA Splicing.

    Dauksaite, V., Akusjärvi, G. (2002). The Journal of Biological Chemistry, vol. 277, ss. 12579-12586
  • Human splicing factor ASF/SF2 encodes for a repressor domain required for its inhibitory activity on pre-mRNA splicing.

    Dauksaite, V., Akusjärvi, G. (2002). Journal of Biological Chemistry, vol. 277, ss. 12579-12586 DOI
  • Functional inactivation of the SR family of splicing factors during a vaccinia virus infection.

    Huang, T., Estmer Nilsson, C., Punga, T., Akusjärvi, G. (2002). EMBO Reports, vol. 3, ss. 1088-1093 DOI
  • Messenger RNA in eukaryotes.

    Kreivi, J., Petersen-Mahrt, S., Akusjärvi, G. (2002). I Encyclopedia of Life Sciences .
  • Unscheduled expression of capsid protein IIIa results in defects in adenovirus major late mRNA and protein expression.

    Molin, M., Bouakaz, L., Berenjian, S., Akusjärvi, G. (2002). Virus Research, vol. 83, ss. 197-206
  • Adenovirus vector designed for expression of toxic proteins.

    Edholm, D., Molin, M., Bajak, E., Akusjärvi, G. (2001). Journal of Virology, vol. 75, ss. 9579-9584 DOI
  • The adenovirus E4-ORF4 splicing enhancer protein interacts with a subsetof phosphorylated SR proteins.

    Estmer Nilsson, C., Petersen-Mahrt, S., Durot, C., Shtrichman, R., Krainer, A. et al. (2001). EMBO Journal, vol. 20, ss. 864-871 DOI
  • Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner.

    Mandic, A., Viktorsson, K., Molin, M., Akusjärvi, G., Eguchi, H. et al. (2001). Molecular and Cellular Biology, vol. 21, ss. 3684-3691 DOI
  • Regulation of gene expression.

    Akusjärvi, G. (2000). I The Encyclopedia of Physical Science and Technology, . ss. 501-517
  • Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cellgrowth, induces replicative senescence, and inhibits telomerase activitysimilarly to p16INK4A.

    Fuxe, J., Akusjärvi, G., Goike, H., Roos, G., Collins, V. et al. (2000). Cell growth & differentiation, vol. 11, ss. 373-384
  • Overexpression of essential splicing factor ASF/SF2 blocks the temporalshift in adenovirus pre-mRNA splicing and reduces virus progeny formation.

    Molin, M., Akusjärvi, G. (2000). Journal of Virology, vol. 74, ss. 9002-9009
  • A novel type of splicing enhancer regulating adenovirus pre-mRNA splicing.

    Mühlemann, O., Yue, B., Petersen-Mahrt, S., Akusjärvi, G. (2000). Molecular and Cellular Biology, vol. 20, ss. 2317-2325
  • The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex..

    Punga, T., Akusjärvi, G. (2000). FEBS Letters, vol. 476, ss. 248-252
  • The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex.

    Punga, T., Akusjärvi, G. (2000). FEBS Letters, vol. 476, ss. 248-252 DOI
  • Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin.

    Viktorsson, K., Heiden, T., Molin, M., Akusjärvi, G., Linder, S. et al. (2000). Apoptosis (London), vol. 5, ss. 355-367 DOI
  • Functional coexpression of serine protein kinase SRPK1 and its substrateASF/SF2 in Escherichia coli.

    Yue, B., Ajuh, P., Akusjärvi, G., Lamond, A., Kreivi, J. (2000). Nucleic Acids Research, vol. 28, ss. e14- DOI
  • Remodelling of the host cell RNA splicing machinery during an adenovirus infection.

    Akusjärvi, G. (1999). I Pandalai, S.G. (red.) Recent research developments in Virology, Trivandrum: Transworld Research Network. ss. 621-
  • Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein.

    Mannervik, M., Fan, S., Ström, A., Helin, K., Akusjärvi, G. (1999). Virology, vol. 256, ss. 313-321 DOI
  • The splicing factor-associated protein, p32, regulates RNA splicing byinhibiting ASF/SF2 RNA binding and phosphorylation.

    Petersen-Mahrt, S., Estmer, C., Öhrmalm, C., Matthews, D., Russell, W. et al. (1999). EMBO Journal, vol. 18, ss. 1014-1024 DOI
  • The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phophorylation.

    Petersen-Mahrt, S., Estmer, C., Öhrmalm, C., Matthews, D., Russell, W. et al. (1999). EMBO Journal, vol. 18, ss. 1014-1024
  • A downstream splicing enhancer is essential for in vitro pre-mRNA splicing.

    Yue, B., Akusjärvi, G. (1999). FEBS Letters, vol. 451, ss. 10-14 DOI
  • Regulation of adenovirus alternative RNAsplicing by dephosphorylation of SR proteins.

    Kanopka, A., Mühleman, O., Petersen-Mahrt, S., Estmer, C., Öhrmalm, C. et al. (1998). Nature, vol. 393, ss. 185-187 DOI
  • Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins.

    Kanopka, A., Mühlemann, O., Petersen-Mahrt, S., Estmer, C., Öhrmalm, C. et al. (1998). Nature, vol. 393, ss. 185-187
  • Two Novel Adenovirus Vector Systems Permitting Regulated Protein Expression in Gene Transfer Experiments.

    Molin, M., Shoshan, M., Öhman-Forslund, K., Linder, S., Akusjärvi, G. (1998). Journal of Virology, vol. 72, ss. 8358-8861
  • Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments.

    Molin, M., Shoshan, M., Öhman-Forslund, K., Linder, S., Akusjärvi, G. (1998). Journal of Virology, vol. 72, ss. 8358-8361
  • Preparation of splicing competent nuclear extracts from adenovirus infected cells.

    Mühlemann, O., Akusjärvi, G. (1998). I William S.M. Woold (red.) Adenovirus Methods and Protocols, Totowa, New Jersey: Humana Press Inc. ss. 203-216 DOI
  • AR1 is an integral part of the adenovirus-2 E1A CR3 transactivation domain.

    Ström, A., Ohlson, P., Akusjärvi, G. (1998). Journal of Virology, vol. 72, ss. 5978-5983
  • The transcriptionalco-activator proteins p300 and CBP stimulate adenovirus E1A conservedregion 1 transactivation independent of a direct interaction.

    Mannervik, M., Akusjärvi, G. (1997). FEBS Letters, vol. 414, ss. 111-116 DOI
  • Adenoviruses.

    Ruuskanen, O., Meurman, O., Akusjärvi, G. (1997). I D. Richnmond, R. Whitley, F. Hayden (red.) Clinical Virology New York: ChurchillLivingstone Inc.
  • Gene expression, regulation of.

    Akusjärvi, G. (1996). I R.A. Meyers (red.) Encyclopedia of molecular biology and Molecular Medicine, . ss. 364-375
  • Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter.

    Bondesson, M., Ohman, K., Mannervik, M., Fan, S., Akusjärvi, G. (1996). Journal of Virology, vol. 70, ss. 3844-6851
  • Inhibition by SRproteins of splicing of a regulated adenovirus pre-mRNA.

    Kanopka, A., Mühleman, O., Akusjärvi, G. (1996). Nature, vol. 381, ss. 535-538 DOI
  • Gene expression, regulation of.

    Akusjärvi, G. (1995). I R. A. Meyers (red.) The Encyclopedia of Molecular Biology and Biotechnology, . ss. 346-
  • Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

    Carvalho, T., Seeler, J., Ohman, K., Jordan, P., Pettersson, U. et al. (1995). Journal of Cell Biology, vol. 131, ss. 45-56
  • Splicing of two weak 3' splice sites from the adenovirus major late region is enhanced innuclear extracts from adenovirus infected cells.

    Muhlemann, O., Kreivi, J., Akusjärvi, G. (1995). Nucleic Acids Symposium Series, ss. 220-223
  • Enhanced splicing of nonconsensus 3' splice sites late during adenovirus infection.

    Mühlemann, O., Kreivi, J., Akusjärvi, G. (1995). Journal of Virology, vol. 69, ss. 7324-7327
  • Regulation of adenovirus alternative RNA splicing by PKA, DNA-PK, PP2A and SR proteins.

    Kvissel, A., Törmänen-Persson, H., Aksaas, A., Akusjärvi, G., Skålhegg, B. I
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