Publications

Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development.
Habicher, J., Varshney, G., Waldmann, L., Snitting, D., Allalou, A. et al. (2022). PLOS Genetics, . vol. 18 DOI
A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation.
Missaghian, P., Dierker, T., Khosrowabadi, E., Axling, F., Eriksson, I. et al. (2022). Glycobiology, . vol. 32, ss. 518-528 DOI
Heparan Sulfate Biosynthesis in Zebrafish.
Gorniok, B., Habicher, J., Ledin, J., Kjellén, L. (2021). Journal of Histochemistry and Cytochemistry, . vol. 69, ss. 49-60 DOI
Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
Bachvarova, V., Dierker, T., Esko, J., Hoffmann, D., Kjellén, L. et al. (2020). Matrix Biology, . vol. 93, ss. 43-59 DOI
Establishment and characterization of Drosophila cell lines mutant for heparan sulfate modifying enzymes.
Nakato, E., Liu, X., Eriksson, I., Yamamoto, M., Kinoshita-Toyoda, A. et al. (2019). Glycobiology, . vol. 29, ss. 479-489 DOI
Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules.
Frisk, J., Kjellén, L., Melo, F., Öhrvik, H., Pejler, G. (2018). Frontiers in Immunology, . vol. 9 DOI
Specificity of glycosaminoglycan-protein interactions.
Kjellén, L., Lindahl, U. (2018). Current opinion in structural biology, . vol. 50, ss. 101-108 DOI
Expanding the chondroitin glycoproteome of Caenorhabditis elegans.
Noborn, F., Toledo, A., Nasir, W., Nilsson, J., Dierker, T. et al. (2018). Journal of Biological Chemistry, vol. 293, ss. 379-389 DOI
Separation and Purification of Glycosaminoglycans (GAGs) from Caenorhabditis elegans.
Dierker, T., Kjellén, L. (2017). Bio-protocol, vol. 7 DOI
Identification of novel chondroitin sulfate sulfotransferases and proteoglycan core proteins in the nematode C. elegans.
Dierker, T., Noborn, F., Hinas, A., Kjellén, L. (2017). International journal of experimental pathology (Print), vol. 98, ss. A4-A4
Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells.
Hu Frisk, J., Kjellén, L., Kaler, S., Pejler, G., Öhrvik, H. (2017). Journal of Immunology, vol. 199, ss. 4132-4141 DOI
Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation..
Xiong, A., Kundu, S., Forsberg, M., Xiong, Y., Bergström, T. et al. (2017). Matrix Biology, vol. 62, ss. 92-104 DOI
Versican accumulates in vascular lesions in pulmonary arterial hypertension.
Chang, Y., Chan, C., Eriksson, I., Johnson, P., Cao, X. et al. (2016). PULMONARY CIRCULATION, vol. 6, ss. 347-359 DOI
NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length.
Deligny, A., Dierker, T., Dagälv, A., Lundequist, A., Eriksson, I. et al. (2016). Journal of Biological Chemistry, vol. 291, ss. 18600-18607 DOI
Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.
Dierker, T., Bachvarova, V., Krause, Y., Li, J., Kjellen, L. et al. (2016). Matrix Biology, vol. 49, ss. 82-92 DOI
Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans.
Dierker, T., Shao, C., Haitina, T., Zaia, J., Hinas, A. et al. (2016). Scientific Reports, vol. 6 DOI
Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis.
Menard, J., Christianson, H., Kucharzewska, P., Bourseau-Guilmain, E., Svensson, K. et al. (2016). Cancer Research, vol. 76, ss. 4828-4840 DOI
Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice.
Roy, A., Sawesi, O., Pettersson, U., Dagälv, A., Wattrang, E. et al. (2016). BMC Immunology, vol. 17 DOI
The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation.
Filipek-Gorniok, B., Carlsson, P., Haitina, T., Habicher, J., Ledin, J. et al. (2015). PLOS ONE, vol. 10 DOI
Identification of Chondroitin Sulfate Linkage Region Glycopeptides Reveals Prohormones as a Novel Class of Proteoglycans.
Noborn, F., Toledo, A., Sihlbom, C., Lengqvist, J., Fries, E. et al. (2015). Molecular & Cellular Proteomics, vol. 14, ss. 41-49 DOI
Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture C-13-glucose metabolic labeling.
Pegeot, M., Sadir, R., Eriksson, I., Kjellén, L., Simorre, J. et al. (2015). Glycobiology, vol. 25, ss. 151-156 DOI
Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans.
Öhrvik, H., Logeman, B., Noguchi, G., Eriksson, I., Kjellen, L. et al. (2015). Journal of Immunology, vol. 195, ss. 3654-3664 DOI
Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation.
Roy, A., Ganesh, G., Sippola, H., Bolin, S., Sawesi, O. et al. (2014). Journal of Biological Chemistry, vol. 289, ss. 237-250 DOI
Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development.
Filipek-Gorniok, B., Holmborn, K., Haitina, T., Habicher, J., Oliveira, M. et al. (2013). Developmental Dynamics, vol. 242, ss. 964-975 DOI
Distorted Secretory Granule Composition in Mast Cells with Multiple Protease Deficiency.
Grujic, M., Calounova, G., Eriksson, I., Feyerabend, T., Rodewald, H. et al. (2013). Journal of Immunology, vol. 191, ss. 3931-3938 DOI
MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA).
Kasza, Z., Fredlund Fuchs, P., Tamm, C., Eriksson, A., O'Callaghan, P. et al. (2013). Journal of Biological Chemistry, vol. 288, ss. 25956-25963 DOI
Pathophysiology of heparan sulphate: many diseases, few drugs.
Lindahl, U., Kjellén, L. (2013). Journal of Internal Medicine, vol. 273, ss. 555-571 DOI
Dimerized Glycosaminoglycan Chains Increase FGF Signaling during Zebrafish Development.
Nguyen, T., Tran, V., Sorna, V., Eriksson, I., Kojima, A. et al. (2013). ACS Chemical Biology, vol. 8, ss. 939-948 DOI
Heparin biosynthesis.
Carlsson, P., Kjellén, L. (2012). Handbook of experimental pharmacology, vol. 207, ss. 23-41 DOI
Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells.
Forsberg, M., Holmborn, K., Kundu, S., Dagälv, A., Kjellén, L. et al. (2012). Journal of Biological Chemistry, vol. 287, ss. 10853-10862 DOI
Glycobiology: Enzyme deficiencies deciphered.
Kjellén, L. (2012). Nature chemical biology, vol. 8, ss. 137-138 DOI
Heparan Sulfate Biosynthesis: Regulation and Variability.
Kreuger, J., Kjellén, L. (2012). Journal of Histochemistry and Cytochemistry, vol. 60, ss. 898-907 DOI
Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis.
Le Jan, S., Hayashi, M., Kasza, Z., Eriksson, I., Bishop, J. et al. (2012). Arteriosclerosis, Thrombosis and Vascular Biology, vol. 32, ss. 1255-1263 DOI
Heparan Sulfate Biosynthesis Enzymes in Embryonic Stem Cell Biology.
Tamm, C., Kjellén, L., Li, J. (2012). Journal of Histochemistry and Cytochemistry, vol. 60, ss. 943-949 DOI
Lowered Expression of Heparan Sulfate/Heparin Biosynthesis Enzyme N-Deacetylase/N-Sulfotransferase 1 Results in Increased Sulfation of Mast Cell Heparin.
Dagälv, A., Holmborn, K., Kjellén, L., Åbrink, M. (2011). Journal of Biological Chemistry, vol. 286, ss. 44433-44440 DOI
Mucopolysaccharidosis Type I, Unique Structure of Accumulated Heparan Sulfate and Increased N-Sulfotransferase Activity in Mice Lacking alpha-L-iduronidase.
Holley, R., Deligny, A., Wei, W., Watson, H., Ninonuevo, M. et al. (2011). Journal of Biological Chemistry, vol. 286, ss. 37515-37524 DOI
Mesomelia-Synostoses Syndrome Results from Deletion of SULF1 and SLCO5A1 Genes at 8q13.
Isidor, B., Pichon, O., Redon, R., Day-Salvatore, D., Hamel, A. et al. (2010). American Journal of Human Genetics, vol. 87, ss. 95-100 DOI
Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1..
Ringvall, M., Kjellén, L. (2010). Progress in molecular biology and translational science, vol. 93, ss. 35-58 DOI
Heparin/heparan sulfate biosynthesis: Processive formation of N-sulfated domains.
Carlsson, P., Presto, J., Spillmann, D., Lindahl, U., Kjellén, L. (2008). Journal of Biological Chemistry, vol. 283, ss. 20008-20014 DOI
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization.
Kawamura, H., Li, X., Goishi, K., van Meeteren, L., Jakobsson, L. et al. (2008). Blood, vol. 112, ss. 3638-49 DOI
Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.
Presto, J., Thuveson, M., Carlsson, P., Busse, M., Wilén, M. et al. (2008). Proceedings of the National Academy of Sciences of the United States of America, vol. 105, ss. 4751-4756 DOI
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.
Abramsson, A., Kurup, S., Yamada, S., Lindblom, P., Schallmeiner, E. et al. (2007). Genes & Development, vol. 21, ss. 316-331 DOI
Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.
Busse, M., Feta, A., Presto, J., Wilén, M., Grønning, M. et al. (2007). Journal of Biological Chemistry, vol. 282, ss. 32802-32810 DOI
Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis.
Jakobsson, L., Kreuger, J., Holmborn, K., Lundin, L., Eriksson, I. et al. (2006). Developmental Cell, vol. 10, ss. 625-634
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.
Kurup, S., Abramsson, A., Li, J., Lindahl, U., Kjellén, L. et al. (2006). Biochemical Society Transactions, vol. 34, ss. 454-455
Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.
Ledin, J., Ringvall, M., Thuveson, M., Eriksson, I., Wilén, M. et al. (2006). Journal of Biological Chemistry, vol. 281, ss. 35727-35734 DOI
No change in glomerular heparan sulfate structure in early human and experimental diabetic nephropathy.
van den Born, J., Pisa, B., Bakker, M., Celie, J., Straatman, C. et al. (2006). Journal of Biological Chemistry, vol. 281, ss. 29606-29613 DOI
Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.
Holmborn, K., Ledin, J., Smeds, E., Eriksson, I., Kusche-Gullberg, M. et al. (2004). The Journal of Biological Chemistry, vol. 279 279, ss. 42355 42355-58 58
Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups..
Holmborn, K., Ledin, J., Smeds, E., Eriksson, I., Kusche-Gullberg, M. et al. (2004). J Biol Chem, vol. 279, ss. 42355-8
Neurogenic inflammation in mice deficient in heparin-synthesizing enzyme..
Karlsen, T., Iversen, V., Forsberg, E., Kjellén, L., Reed, R. et al. (2004). Am J Physiol Heart Circ Physiol, vol. 286, ss. H884-8
Heparan sulfate structure in mice with genetically modified heparan sulfate production..
Ledin, J., Staatz, W., Li, J., Götte, M., Selleck, S. et al. (2004). J Biol Chem, vol. 279, ss. 42732-41
Distinct effects on heparan sulfate structure by different active site mutations in NDST-1.
Bengtsson, J., Eriksson, I., Kjellén, L. (2003). Biochemistry, vol. 42, ss. 2110-2115
Antibody-based assay for N-deacetylase activity of heparan sulfate/heparinN-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1and -2..
Van Den Born, J., Pikas, D., Pisa, B., Eriksson, I., Kjellen, L. et al. (2003). Glycobiology, vol. 13, ss. 1-
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes..
Grobe, K., Ledin, J., Ringvall, M., Holmborn, K., Forsberg, E. et al. (2002). Biochimica et Biophysica Acta - General Subjects, vol. 1573, ss. 209-215
Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1.
Ringvall, M., Ledin, J., Holmborn, K., van Kuppevelt, T., Ellin, F. et al. (2000). Journal of Biological Chemistry, vol. 275, ss. 25926-25930 DOI
Abnormal mast cells in mice deficient in a heparin-sythesizing enzyme.
Forsberg, E., Pejler, G., Ringvall, M., Lunderius, C., Tomasini-Johansson, B. et al. (1999). Nature, vol. 400, ss. 773-776
Biosynthesis of heparin / heparan sulfate: cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung.
Li, J., Hagner-McWhirther, Å., Kjellén, L., Palgi, J., Jalkanen, M. et al. (1997). Journal of Biological Chemistry, vol. 272, ss. 28158-28163 DOI
More to "heparin" than anticoagulation.
Lindahl, U., Lidholt, K., Spillmann, D., Kjellén, L. (1994). Thrombosis Research, vol. 75, ss. 1-32
In vivo regulation of liver heparan sulfate biosynthesis in NDST1 and NDST2 deficient mice.
Ledin, J., Ringvall, M., Eriksson, I., Wilén, M., Thuveson, M. et al.