Publications

Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival.
Lin, C., Basu, K., Ruusala, A., Kozlova, I., Li, Y. et al. (2023). Cancers, . vol. 15 DOI
Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells.
Karalis, T., Shiau, A., Gahman, T., Skandalis, S., Heldin, C. et al. (2022). Cancers, . vol. 14 DOI
Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo.
Tonge, J., Notley, S., Dunning, M., Lopez-Guajardo, A., Medcale, J. et al. (2022). Scientific Reports, . vol. 12 DOI
CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence.
Kolliopoulos, C., Ali, M., Castillejo-Lopez, C., Heldin, C., Heldin, P. (2022). Cancers, . vol. 14 DOI
The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism.
Parnigoni, A., Caon, I., Teo, W., Hua, S., Moretto, P. et al. (2022). Matrix Biology, . vol. 109, ss. 140-161 DOI
Plasma Hyaluronan Decreases During ICU Stay in COVID-19 Survivors but Not inNon-Survivor: A Retrospective Cohort Study.
van der Heijden, J., Kolliopoulos, C., Stattin, K., Lipcsey, M., Frithiof, R. et al. (2021). Biomarkers Journal, vol. 7
Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study.
van der Heijden, J., Kolliopoulos, C., Skorup, P., Sallisalmi, M., Heldin, P. et al. (2021). Intensive Care Medicine Experimental, . vol. 9 DOI
TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation.
Kolliopoulos, C., Chatzopoulos, A., Skandalis, S., Heldin, C., Heldin, P. (2021). Cancers, . vol. 13 DOI
Intracellular hyaluronan: Importance for cellular functions.
Skandalis, S., Karalis, T., Heldin, P. (2020). Seminars in Cancer Biology, . vol. 62, ss. 20-30 DOI
Involvement of hyaluronan and CD44 in cancer and viral infections.
Heldin, P., Kolliopoulos, C., Lin, C., Heldin, C. (2020). Cellular Signalling, . vol. 65 DOI
High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity.
Lin, C., Kolliopoulos, C., Huang, C., Tenhunen, J., Heldin, C. et al. (2019). EBioMedicine, . vol. 48, ss. 425-441 DOI
Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).
Melero-Fernandez de Mera, R., Arasu, U., Karna, R., Oikari, S., Rilla, K. et al. (2019). Matrix Biology, vol. 80, ss. 85-103 DOI
Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.
Karalis, T., Heldin, P., Vynios, D., Neill, T., Buraschi, S. et al. (2019). Matrix Biology, . vol. 78-79, ss. 118-138 DOI
Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production.
Heldin, P., Lin, C., Kolliopoulos, C., Chen, Y., Skandalis, S. (2019). Matrix Biology, . vol. 78-79, ss. 100-117 DOI
Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.
Kolliopoulos, C., Raja, E., Razmara, M., Heldin, P., Heldin, C. et al. (2019). Journal of Biological Chemistry, vol. 294, ss. 4119-4136 DOI
Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer.
Kolliopoulos, C., Lin, C., Heldin, C., Moustakas, A., Heldin, P. (2019). Matrix Biology, vol. 80, ss. 29-45 DOI
The role of deubiquitinating enzyme USP17, hyaluronan synthase 2, and hyaluronan in non-small-cell lung cancer oncogenic transformation.
Mehic, M., de Sa, V., Hebestreit, S., Heldin, P., Heldin, C. (2018). Clinical Cancer Research, vol. 24, ss. 96-96 DOI
The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.
Mehić, M., de Sa, V., Hebestreit, S., Heldin, C., Heldin, P. (2017). Oncogenesis, vol. 6 DOI
Fluorescence Resonance Energy Transfer (FRET) and Proximity Ligation Assays Reveal Functionally Relevant Homo-and Heteromeric Complexes among Hyaluronan Synthases HAS1, HAS2, and HAS3.
Bart, G., Vico, N., Hassinen, A., Pujol, F., Deen, A. et al. (2015). Journal of Biological Chemistry, vol. 290, ss. 11479-11490 DOI
Proteoglycans/Glycosaminoglycans: from basic research to clinical practice.
Tzanakakis, G., Kovalszky, I., Heldin, P., Nikitovic, D. (2014). BioMed Research International, vol. 2014 DOI
Advances in Cancer Research: Hyaluronan Signaling And Turnover, Volume One Hundred And Twenty Three, Preface.
Simpson, M., Heldin, P. (2014). I Simpson, MA andHeldin, P (red.) Hyaluronan Signaling and Turnover, . ss. 15-16
Preface.
Simpson, M., Heldin, P. (2014). Advances in Cancer Research, vol. 123, ss. xv-xvi DOI
HAS2 and CD44 in Breast Tumorigenesis.
Heldin, P., Basu, K., Kozlova, I., Porsch, H. (2014). I Simpson, MA and Heldin, P (red.) Hyaluronan Signaling and Turnover, . ss. 211-229 DOI
Platelet-derived Growth Factor beta-Receptor, Transforming Growth Factor beta Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability.
Porsch, H., Mehic, M., Olofsson, B., Heldin, P., Heldin, C. (2014). Journal of Biological Chemistry, vol. 289, ss. 19747-19757 DOI
Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer.
Heldin, P., Basu, K., Olofsson, B., Porsch, H., Kozlova, I. et al. (2013). Journal of Biochemistry (Tokyo), vol. 154, ss. 395-408 DOI
Efficient TGF beta-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.
Porsch, H., Bernert, B., Mehić, M., Theocharis, A., Heldin, C. et al. (2013). Oncogene, vol. 32, ss. 4355-4365 DOI
IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation.
Kozlova, I., Ruusala, A., Voytyuk, O., Skandalis, S., Heldin, P. (2012). Cellular Signalling, vol. 24, ss. 1856-1862 DOI
Stimulatory effects of pleural fluids from mesothelioma patients on CD44 expression, hyaluronan production and cell proliferation in primary cultures of normal mesothelial and transformed cells.
Teder, P., Versnel, M., Heldin, P. (1996). Int J Cancer, vol. 67, ss. 393-398
Characterization of the mechanism involved in bleomycin-induced increased hyaluronan production in rat lung.
Teder, P., Nettelbladt, O., Heldin, P. (1995). Am. J. Respir. Cell Mol. Biol., vol. 12, ss. 181-189
Hyaluronan production regulation from porcine hyalocyte cell line by cytokines.
Nishitsuka, K., Kashiwagi, Y., Tojo, N., Kanno, C., Takahashi, Y. et al. (2007). Experimental Eye Research, vol. 85, ss. 539-545 DOI
Hyaluronan synthase in trabecular meshwork cells..
Usui, T., Nakajima, F., Ideta, R., Kaji, Y., Suzuki, Y. et al. (2003). Br J Ophthalmol, vol. 87, ss. 357-60
Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts.
Gianoukakis, A., Jennings, T., King, C., Sheehan, C., Hoa, N. et al. (2007). Endocrinology, vol. 148, ss. 54-62 DOI
Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.
Udabage, L., Brownlee, G., Waltham, M., Blick, T., Walker, E. et al. (2005). Cancer Research, vol. 65, ss. 6139-6150 DOI
Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner..
Takahashi, Y., Li, L., Kamiryo, M., Asteriou, T., Moustakas, A. et al. (2005). J Biol Chem
Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44.
Li, L., Heldin, C., Heldin, P. (2006). Journal of Biological Chemistry, vol. 281, ss. 26512-26519 DOI
Hyaluronan and its binding proteins in the epithelium and intraluminal fluid of the bovine oviduct.
Bergqvist, A., Yokoo, M., Heldin, P., Frendin, J., Sato, E. et al. (2005). Zygote (Cambridge. Print), . vol. 13, ss. 207-218 DOI
Phase I and Pharmacokinetic Evaluation of Intravenous Hyaluronic Acid in Combination with Doxorubicin or 5-Fluorouracil.
Rosenthal, M., Gibbs, P., Brown, T., Wong, S., Uren, S. et al. (2005). Chemotherapy, vol. 51, ss. 132-141 DOI
Hyaluronan production increases the malignant properties of mesotheliomacells..
Li, Y., Heldin, P. (2001). Br J Cancer, vol. 85, ss. 600-
Hgf/sf induces mesothelial cell migration and proliferation by autocrineand paracrine pathways..
Warn, R., Harvey, P., Warn, A., Foley-Comer, A., Heldin, P. et al. (2001). Exp Cell Res, vol. 267, ss. 258-
Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44-mediated mechanism..
Rahmanian, M., Heldin, P. (2002). Int J Cancer, vol. 97, ss. 601-
Improvement of rat liver graft function after storage in University ofWisconsin solution containing testicular hyaluronidase..
Papanikolaou, V., Vrochides, D., Gakis, D., Patsiaoura, K., Margari, P. et al. (2002). Liver Transpl, vol. 8, ss. 1028-
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors..
Jacobson, A., Rahmanian, M., Rubin, K., Heldin, P. (2002). Int J Cancer, vol. 102, ss. 212-