Publications

The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma.
Caja, L., Dadras, M., Mezheyeuski, A., Mendes Rodrigues-Junior, D., Liu, S. et al. (2022). Journal of Cellular Physiology, . vol. 237, ss. 743-762 DOI
CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence.
Kolliopoulos, C., Ali, M., Castillejo-Lopez, C., Heldin, C., Heldin, P. (2022). Cancers, . vol. 14 DOI
Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling.
Sarri, N., Wang, K., Tsioumpekou, M., Castillejo-Lopez, C., Lennartsson, J. et al. (2022). Cellular and Molecular Life Sciences (CMLS), . vol. 79 DOI
The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells.
Song, J., Zhou, Y., Yakymovych, I., Schmidt, A., Li, C. et al. (2022). EBioMedicine, . vol. 82 DOI
PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A.
Tanabe, R., Miyazono, K., Todo, T., Saito, N., Iwata, C. et al. (2022). Molecular Oncology, . vol. 16, ss. 269-288 DOI
Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells.
Tsirigoti, C., Ali, M., Maturi, V., Heldin, C., Moustakas, A. (2022). Cell Death and Disease, . vol. 13 DOI
TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition.
Tsubakihara, Y., Ohata, Y., Okita, Y., Younis, S., Eriksson, J. et al. (2022). Molecular Oncology, . vol. 16, ss. 2330-2354 DOI
The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling.
Yakymovych, I., Yakymovych, M., Hamidi, A., Landström, M., Heldin, C. (2022). Science Signaling, . vol. 15 DOI
The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma.
Dadras, M., Caja, L., Mezheyeuski, A., Liu, S., Gelabert, C. et al. (2021). Cell Death and Disease, . vol. 12 DOI
BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells.
Fukuda, T., Fukuda, R., Koinuma, D., Moustakas, A., Miyazono, K. et al. (2021). Cellular Signalling, . vol. 87 DOI
Tumor Promoting Effect of BMP Signaling in Endometrial Cancer.
Fukuda, T., Fukuda, R., Miyazono, K., Heldin, C. (2021). International Journal of Molecular Sciences, . vol. 22 DOI
TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation.
Kolliopoulos, C., Chatzopoulos, A., Skandalis, S., Heldin, C., Heldin, P. (2021). Cancers, . vol. 13 DOI
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling.
Papoutsoglou, P., Rodrigues Junior, D., Morén, A., Bergman, A., Pontén, F. et al. (2021). Oncogene, . vol. 40, ss. 3748-3765 DOI
BMP signaling is a therapeutic target in ovarian cancer.
Fukuda, T., Fukuda, R., Tanabe, R., Koinuma, D., Koyama, H. et al. (2020). Cell Death Discovery, vol. 6 DOI
Involvement of hyaluronan and CD44 in cancer and viral infections.
Heldin, P., Kolliopoulos, C., Lin, C., Heldin, C. (2020). Cellular Signalling, . vol. 65 DOI
TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness.
Sundqvist, A., Vasilaki, E., Voytyuk, O., Bai, Y., Morikawa, M. et al. (2020). Oncogene, . vol. 39, ss. 4436-4449 DOI
Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells.
Thakur, N., Hamidi, A., Song, J., Itoh, S., Bergh, A. et al. (2020). iScience, . vol. 23 DOI
Smad7 Enhances TGF-b-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells.
Thakur, N., Hamidi, A., Song, J., Itoh, S., Bergh, A. et al. (2020). iScience, . vol. 23
Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression.
Tsioumpekou, M., Cunha, S., Ma, H., Åhgren, A., Cedervall, J. et al. (2020). Theranostics, . vol. 10, ss. 1122-1135 DOI
Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B.
Zarei, O., Sarri, N., Dastmalchi, S., Zokai, F., Papadopoulos, N. et al. (2020). Bioorganic chemistry (Print), vol. 94 DOI
Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis.
Zhang, Y., Cedervall, J., Hamidi, A., Herre, M., Viitaniemi, K. et al. (2020). Cancer Research, . vol. 80, ss. 3345-3358 DOI
Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer.
Kolliopoulos, C., Lin, C., Heldin, C., Moustakas, A., Heldin, P. (2019). Matrix Biology, vol. 80, ss. 29-45 DOI
Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.
Kolliopoulos, C., Raja, E., Razmara, M., Heldin, P., Heldin, C. et al. (2019). Journal of Biological Chemistry, vol. 294, ss. 4119-4136 DOI
High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity.
Lin, C., Kolliopoulos, C., Huang, C., Tenhunen, J., Heldin, C. et al. (2019). EBioMedicine, . vol. 48, ss. 425-441 DOI
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
Morikawa, M., Mitani, Y., Holmborn, K., Kato, T., Koinuma, D. et al. (2019). Science Signaling, . vol. 12 DOI
LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation.
Morén, A., Bellomo, C., Tsubakihara, Y., Kardassis, D., Mikulits, W. et al. (2019). Oncogenesis, vol. 8 DOI
The TGFB2-AS1 lncRNA Regulates TGF-beta Signaling by Modulating Corepressor Activity.
Papoutsoglou, P., Tsubakihara, Y., Caja, L., Morén, A., Pallis, P. et al. (2019). Cell reports, . vol. 28, ss. 3182-3198.E11 DOI
The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity.
Papoutsoglou, P., Tsubakihara, Y., Caja, L., Pallis, P., Ameur, A. et al. (2019). Cell reports, . vol. 28, ss. 3182-3198.e11 DOI
JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses.
Sundqvist, A., Voytyuk, O., Hamdi, M., Popeijus, H., Bijlsma-van der Burgt, C. et al. (2019). CELLS, . vol. 8 DOI
Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner.
Yin, R., Eger, G., Sarri, N., Rorsman, C., Heldin, C. et al. (2019). Biochemical and Biophysical Research Communications - BBRC, vol. 519, ss. 469-474 DOI
Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.
Bellomo, C., Caja, L., Fabregat, I., Mikulits, W., Kardassis, D. et al. (2018). Cell Death and Differentiation, vol. 25, ss. 885-903 DOI
Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells.
Caja, L., Tzavlaki, K., Dadras, M., Tan, E., Hatem, G. et al. (2018). Oncogene, vol. 37, ss. 2515-2531 DOI
TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.
Kawasaki, N., Isogaya, K., Dan, S., Yamori, T., Takano, H. et al. (2018). CELL DISCOVERY, . vol. 4 DOI
Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells.
Maturi, V., Enroth, S., Heldin, C., Moustakas, A. (2018). Journal of Cellular Physiology, vol. 233, ss. 7113-7127 DOI
Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells.
Maturi, V., Morén, A., Enroth, S., Heldin, C., Moustakas, A. (2018). Molecular Oncology, . vol. 12, ss. 1153-1174 DOI
The role of deubiquitinating enzyme USP17, hyaluronan synthase 2, and hyaluronan in non-small-cell lung cancer oncogenic transformation.
Mehic, M., de Sa, V., Hebestreit, S., Heldin, P., Heldin, C. (2018). Clinical Cancer Research, vol. 24, ss. 96-96 DOI
PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
Papadopoulos, N., Lennartsson, J., Heldin, C. (2018). Journal of Cell Biology, . vol. 217, ss. 1701-1717 DOI
JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion.
Sundqvist, A., Morikawa, M., Ren, J., Vasilaki, E., Kawasaki, N. et al. (2018). Nucleic Acids Research, . vol. 46, ss. 1180-1195 DOI
Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth.
Thijssen, V., Paulis, Y., Nowak-Sliwinska, P., Deumelandt, K., Hosaka, K. et al. (2018). Journal of Pathology, vol. 246, ss. 447-458 DOI
The protein kinase SIK downregulates the polarity protein Par3.
Vanlandewijck, M., Dadras, M., Lomnytska, M., Mahzabin, T., Lee Miller, M. et al. (2018). OncoTarget, vol. 9, ss. 5716-5735 DOI
Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma.
Burmakin, M., van Wieringen, T., Olsson, P., Stuhr, L., Åhgren, A. et al. (2017). Journal of Translational Medicine, . vol. 15 DOI
The TGFβ superfamily in Lisbon: navigating through development and disease.
Christian, J., Heldin, C. (2017). Development, vol. 144, ss. 4476-4480 DOI
Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF beta stimulation in cancer.
Gudey, S., Sundar, R., Heldin, C., Bergh, A., Landström, M. (2017). OncoTarget, . vol. 8, ss. 97703-97726
TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α.
Hamidi, A., Song, J., Thakur, N., Itoh, S., Marcusson, A. et al. (2017). Science Signaling, vol. 10 DOI
The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.
Mehić, M., de Sa, V., Hebestreit, S., Heldin, C., Heldin, P. (2017). Oncogenesis, vol. 6 DOI
The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.
Okita, Y., Kimura, M., Xie, R., Chen, C., Shen, L. et al. (2017). Science Signaling, . vol. 10 DOI
TGF beta and the nuclear receptor LXR alpha crosstalk on lipid metabolism and epithelial to mesenchymal transition in hepatocellular carcinoma.
Bellomo, C., Gahman, T., Shiau, A., Heldin, C., Moustakas, A. (2016). European Journal of Clinical Investigation, vol. 46, ss. 36-36
Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF- Signaling.
Carthy, J., Engstrom, U., Heldin, C., Moustakas, A. (2016). Journal of Cellular Biochemistry, vol. 117, ss. 938-945 DOI
Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.
Carthy, J., Stoeter, M., Bellomo, C., Vanlandewijck, M., Heldin, A. et al. (2016). Scientific Reports, vol. 6 DOI
Signals and Receptors.
Heldin, C., Lu, B., Evans, R., Gutkind, J. (2016). Cold Spring Harbor Perspectives in Biology, vol. 8 DOI
Signaling Receptors for TGF-beta Family Members.
Heldin, C., Moustakas, A. (2016). Cold Spring Harbor Perspectives in Biology, vol. 8 DOI
BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors.
Morikawa, M., Koinuma, D., Mizutani, A., Kawasaki, N., Holmborn, K. et al. (2016). Stem Cell Reports, vol. 6, ss. 64-73 DOI
The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
Raja, E., Tzavlaki, K., Vuilleumier, R., Edlund, K., Kahata, K. et al. (2016). OncoTarget, vol. 7, ss. 1120-1143 DOI
The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor beta (PDGFR beta) Internalization and Signaling.
Rorsman, C., Tsioumpekou, M., Heldin, C., Lennartsson, J. (2016). Journal of Biological Chemistry, vol. 291, ss. 11608-11618 DOI
APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain.
Song, J., Mu, Y., Li, C., Bergh, A., Miaczynska, M. et al. (2016). OncoTarget, vol. 7, ss. 279-292 DOI
Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.
Tsioumpekou, M., Papadopoulos, N., Burovic, F., Heldin, C., Lennartsson, J. (2016). Cellular Signalling, vol. 28, ss. 1422-1431 DOI
Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program.
Vasilaki, E., Morikawa, M., Koinuma, D., Mizutani, A., Hirano, Y. et al. (2016). Science Signaling, vol. 9 DOI
Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.
Watanabe, Y., Papoutsoglou, P., Maturi, V., Tsubakihara, Y., Hottiger, M. et al. (2016). Journal of Biological Chemistry, vol. 291, ss. 12706-12723 DOI
Tamoxifen Inhibits TGF-beta-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.
Carthy, J., Sundqvist, A., Heldin, A., Van Dam, H., Kletsas, D. et al. (2015). Journal of Cellular Physiology, vol. 230, ss. 3084-3092 DOI
Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation.
Ma, H., Wardega, P., Mazaud, D., Klosowska-Wardega, A., Jurek, A. et al. (2015). Cellular Signalling, vol. 27, ss. 2209-2219 DOI
TRAF6 promotes TGF beta-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGF beta type I receptor.
Sundar, R., Gudey, S., Heldin, C., Landstrom, M. (2015). Cell Cycle, vol. 14, ss. 554-565 DOI
The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition.
Tan, E., Kahata, K., Idås, O., Thuault, S., Heldin, C. et al. (2015). Nucleic Acids Research, vol. 43, ss. 162-178 DOI
Mechanism of platelet-derived growth factor (PDGF) Erk5 MAP-kinase activation is cell type-dependent and can be independent of PDGF receptor kinase activity.
Tsioumpekou, M., Papadopoulos, N., Burovic, F., Heldin, C., Lennartsson, J. (2015). International Journal of Molecular Medicine, vol. 36, ss. S20-S20
Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification.
Vanlandewijck, M., Lebouvier, T., Mae, M., Nahar, K., Hornemann, S. et al. (2015). PLOS ONE, vol. 10 DOI
CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface.
Yakymovych, I., Yakymovych, M., Zang, G., Mu, Y., Bergh, A. et al. (2015). Journal of Cell Biology, vol. 210, ss. 319-332 DOI
Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling.
Dahl, M., Maturi, V., Lönn, P., Papoutsoglou, P., Zieba, A. et al. (2014). PLOS ONE, vol. 9, ss. e103651- DOI
NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar.
Eger, G., Papadopoulos, N., Lennartsson, J., Heldin, C. (2014). PLOS ONE, vol. 9, ss. e109047- DOI
Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells.
Enroth, S., Andersson, R., Bysani, M., Wallerman, O., Tuch, B. et al. (2014). Nucleic Acids Research, vol. 42, ss. 6921-6934 DOI
Nucleosome regulatory dynamics in response to TGF beta.
Enroth, S., Andersson, R., Bysani, M., Wallerman, O., Termén, S. et al. (2014). Nucleic Acids Research, vol. 42, ss. 6921-6934 DOI
TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1.
Gudey, S., Sundar, R., Mu, Y., Wallenius, A., Zang, G. et al. (2014). Science signaling, vol. 7, ss. ra2- DOI
Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases..
Heldin, C. (2014). Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, vol. 9, ss. 69-79 DOI
Signals and receptors.
Heldin, C., Lu, B., Evans, R., Gutkind, J. (2014). I Cantley, LC (red.) Signal transduction, New York: Cold Spring Harbor Laboratory Press (CSHL). ss. 3-29
Platelet-derived Growth Factor beta-Receptor, Transforming Growth Factor beta Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability.
Porsch, H., Mehic, M., Olofsson, B., Heldin, P., Heldin, C. (2014). Journal of Biological Chemistry, vol. 289, ss. 19747-19757 DOI
TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1.
Thakur, N., Gudey, S., Marcusson, A., Fu, J., Bergh, A. et al. (2014). Cell Cycle, vol. 13, ss. 2400-2414 DOI
Transforming growth factor-ß signaling.
Heldin, C. (2013). I Moustakas A, Miyazono K (red.) TGF-ß in human Disease, . ss. 3-32 DOI
Structural and functional properties of platelet-derived growth factor and stem cell factor receptors.
Heldin, C., Lennartsson, J. (2013). Cold Spring Harbor Perspectives in Biology, vol. 5, ss. UNSP a009100- DOI
The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo..
Lennartsson, J., Ma, H., Wardega, P., Pelka, K., Engström, U. et al. (2013). Journal of Biological Chemistry, vol. 288, ss. 15736-15744 DOI
Coordination of TGF-beta Signaling by Ubiquitylation.
Moustakas, A., Heldin, C. (2013). Molecular Cell, vol. 51, ss. 555-556 DOI
Efficient TGF beta-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.
Porsch, H., Bernert, B., Mehić, M., Theocharis, A., Heldin, C. et al. (2013). Oncogene, vol. 32, ss. 4355-4365 DOI
Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-gamma1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D.
Razmara, M., Heldin, C., Lennartsson, J. (2013). Cell Communication and Signaling, vol. 11 DOI
Dynamin Inhibitors Impair Endocytosis and Mitogenic Signaling of PDGF.
Sadowski, L., Jastrzębski, K., Kalaidzidis, Y., Heldin, C., Hellberg, C. et al. (2013). Traffic, . vol. 14, ss. 725-736 DOI
Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.
Sundqvist, A., Zieba, A., Vasilaki, E., Herrera Hidalgo, C., Söderberg, O. et al. (2013). Oncogene, vol. 32, ss. 3606-3615 DOI
p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.
Termén, S., Tan, E., Heldin, C., Moustakas, A. (2013). Journal of Cellular Physiology, vol. 228, ss. 801-813 DOI
Platelet-derived growth factor.
Östman, A., Heldin, C. (2013). I Gelmann, EP (red.) Molecular oncology, Cambridge: Cambridge University Press. ss. 135-143 DOI
APC and Smad7 link the TGFβ type I receptors to the microtubule system to promote cell migration.
Ekman, M., Mu, Y., Lee, S., Edlund, S., Kozakai, T. et al. (2012). Molecular Biology of the Cell, vol. 23, ss. 2109-2121 DOI
Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.
Hamidi, A., von Bulow, V., Hamidi, R., Winssinger, N., Barluenga, S. et al. (2012). Journal of Biological Chemistry, . vol. 287, ss. 123-133 DOI
Meet the ERC.
Heldin, C. (2012). European Journal of Cancer, vol. 48, ss. S5-S5 DOI
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
Lönn, P., Vanlandewijck, M., Raja, E., Kowanetz, M., Watanabe, Y. et al. (2012). Journal of Biological Chemistry, vol. 287, ss. 12867-12878 DOI
Induction of epithelial-mesenchymal transition by transforming growth factor β.
Moustakas, A., Heldin, C. (2012). Seminars in Cancer Biology, vol. 22, ss. 446-454 DOI
MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis.
Razmara, M., Eger, G., Rorsman, C., Heldin, C., Lennartsson, J. (2012). Cellular Signalling, vol. 24, ss. 635-640 DOI
Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.
Schmees, C., Villaseñor, R., Zheng, W., Ma, H., Zerial, M. et al. (2012). Molecular Biology of the Cell, vol. 23, ss. 2571-2582 DOI
Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition.
Tan, E., Thuault, S., Caja, L., Carletti, T., Heldin, C. et al. (2012). Journal of Biological Chemistry, vol. 287, ss. 7134-7145 DOI
Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase.
Zieba, A., Pardali, K., Söderberg, O., Lindbom, L., Nyström, E. et al. (2012). Molecular & Cellular Proteomics, . vol. 11 DOI
A decisive function of transforming growth factor-β/Smad signaling in tissue morphogenesis and differentiation of human HaCaT keratinocytes.
Buschke, S., Stark, H., Cerezo, A., Prätzel-Wunder, S., Boehnke, K. et al. (2011). Molecular Biology of the Cell, vol. 22, ss. 782-794 DOI
Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation.
Jurek, A., Heldin, C., Lennartsson, J. (2011). Cellular Signalling, vol. 23, ss. 280-287 DOI
Combination therapy using imatinib and vatalanib improves the therapeutic efficiency of paclitaxel towards a mouse melanoma tumor.
Kłosowska-Wardega, A., Hasumi, Y., Åhgren, A., Heldin, C., Hellberg, C. (2011). Melanoma research, . vol. 21, ss. 57-65 DOI
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.
Morikawa, M., Koinuma, D., Tsutsumi, S., Vasilaki, E., Kanki, Y. et al. (2011). Nucleic Acids Research, . vol. 39, ss. 8712-8727 DOI
Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.
Morén, A., Raja, E., Heldin, C., Moustakas, A. (2011). Journal of Biological Chemistry, vol. 286, ss. 341-353 DOI
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.
Mu, Y., Sundar, R., Thakur, N., Ekman, M., Kumar Gudey, S. et al. (2011). Nature Communications, . vol. 2 DOI
The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity.
Zheng, W., Lennartsson, J., Hendriks, W., Heldin, C., Hellberg, C. (2011). Cellular Signalling, vol. 23, ss. 1050-1056 DOI
Filamin A mediates HGF/c-MET signaling in tumor cell migration.
Zhou, A., Toylu, A., Nallapalli, R., Nilsson, G., Atabey, N. et al. (2011). International Journal of Cancer, vol. 128, ss. 839-846 DOI
Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
Bergström, R., Savary, K., Morén, A., Guibert, S., Heldin, C. et al. (2010). Journal of Biological Chemistry, USA: The American Society for Biochemistry and Molecular Biology, Inc.. vol. 285, ss. 19727-19737 DOI
Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.
Cunha, S., Pardali, E., Thorikay, M., Anderberg, C., Hawinkels, L. et al. (2010). Journal of Experimental Medicine, . vol. 207, ss. 85-100 DOI
Protein tyrosine kinase receptor signaling overview.
Heldin, C. (2010). I Ralph A. Bradshaw & Edward A. Dennis (red.) Handbook of Cell Signaling, Amsterdam: Elsevier Ltd. ss. 419-426
PDGF and Vessel Maturation.
Hellberg, C., Östman, A., Heldin, C. (2010). I Rüdiger Liersch, Wolfgang E. Berdel, Torsten Kessler (red.) Angiogenesis inhibition, . ss. 103-114 DOI
The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.
Karousou, E., Kamiryo, M., Skandalis, S., Ruusala, A., Asteriou, T. et al. (2010). Journal of Biological Chemistry, USA: The American Society for Biochemistry and Molecular Biology, Inc.. vol. 285, ss. 23647-23654 DOI
Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner.
Krampert, M., Chirasani, S., Wachs, F., Aigner, R., Bogdahn, U. et al. (2010). Molecular and Cellular Biology, . vol. 30, ss. 3685-3694 DOI
Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis.
Lennartsson, J., Burovic, F., Witek, B., Jurek, A., Heldin, C. (2010). Cellular Signalling, . vol. 22, ss. 955-960 DOI
PARP-1 attenuates Smad-mediated transcription.
Lönn, P., van der Heide, L., Dahl, M., Hellman, U., Heldin, C. et al. (2010). Molecular Cell, vol. 40, ss. 521-532 DOI
Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro.
Tian, F., Zhou, A., Smits, A., Larsson, E., Goumans, M. et al. (2010). Biochemical and Biophysical Research Communications - BBRC, . vol. 392, ss. 283-288 DOI
Mutation of tyrosine residue 857 in the PDGF β-receptor affects cell proliferation but not migration.
Wardega, P., Heldin, C., Lennartsson, J. (2010). Cellular Signalling, vol. 22, ss. 1363-1368 DOI
Activation of Protein Kinase C α Is Necessary for Sorting the PDGF β-Receptor to Rab4a-dependent Recycling.
Hellberg, C., Schmees, C., Karlsson, S., Åhgren, A., Heldin, C. (2009). Molecular Biology of the Cell, vol. 20, ss. 2856-2863 DOI
Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom.
Huminiecki, L., Goldovsky, L., Freilich, S., Moustakas, A., Ouzounis, C. et al. (2009). BMC Evolutionary Biology, . vol. 9, ss. 28- DOI
Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation.
Jurek, A., Amagasaki, K., Gembarska, A., Heldin, C., Lennartsson, J. (2009). Journal of Biological Chemistry, vol. 284, ss. 4626-4634 DOI
Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma.
Kłosowska-Wardega, A., Hasumi, Y., Burmakin, M., Åhgren, A., Stuhr, L. et al. (2009). PloS one, vol. 4, ss. e8149- DOI
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
Paulsson, J., Sjöblom, T., Micke, P., Pontén, F., Landberg, G. et al. (2009). American Journal of Pathology, . vol. 175, ss. 334-341 DOI
TGF-beta uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells.
Thakur, N., Sorrentino, A., Heldin, C., Landström, M. (2009). Future oncology (London, England), . vol. 5, ss. 1-3 DOI
Foreword: Transforming Growth Factor-beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy.
Heldin, C. (2008). I Jakowlew, S.B. (red.) Transforming Growth Factor-β in Cancer Therapy, Volume II, Totowa, New Jersey: The Humana Press, Inc.. ss. vii-viii
TGF-beta signaling from receptors to Smads.
Heldin, C. (2008). I Derynck, Rik & Miyazono, Kohei (red.) The TGF-beta Family, Woodbury, N.Y.: Cold Spring Harbor Laboratory Press. ss. 259-285
Feedback Control: The role of negative feedback in signal transduction control.
Heldin, C., Lennartsson, J., Hellberg, C. (2008). European Journal of Human Genetics, . vol. 16, ss. 769-770 DOI
TGFβ induces SIK to negatively regulate type I receptor kinase signaling.
Kowanetz, M., Lönn, P., Vanlandewijck, M., Kowanetz, K., Heldin, C. et al. (2008). Journal of Cell Biology, . vol. 182, ss. 655-662 DOI
A gain-of-function mutation in the PDGFR-beta alters thekinetics of injury response in liver and skin.
Krampert, M., Heldin, C., Heuchel, R. (2008). Laboratory Investigation, . vol. 88, ss. 1204-1214 DOI
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats..
Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S. et al. (2008). Journal of Clinical Investigation, vol. 118, ss. 913-923 DOI
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse.
Pielberg, G., Golovko, A., Sundström, E., Curik, I., Lennartsson, J. et al. (2008). Nature Genetics, vol. 40, ss. 1004-1009 DOI
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.
Ruusala, A., Pawson, T., Heldin, C., Aspenström, P. (2008). Journal of Biological Chemistry, . vol. 283, ss. 30034-30044 DOI
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.
Sorrentino, A., Thakur, N., Grimsby, S., Marcusson, A., von Bulow, V. et al. (2008). Nature Cell Biology, vol. 10, ss. 1199-1207 DOI
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition.
Thuault, S., Tan, E., Peinado, H., Cano, A., Heldin, C. et al. (2008). Journal of Biological Chemistry, vol. 283, ss. 33437-33446 DOI
Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling.
Hasumi, Y., Kłosowska-Wardega, A., Furuhashi, M., Östman, A., Heldin, C. et al. (2007). International Journal of Cancer, vol. 121, ss. 2606-2614 DOI
Cell regulation: Cellular signaling.
Heldin, C., Peter, t. (2007). Current Opinion in Cell Biology, . vol. 19, ss. 109-111 DOI
SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma.
Kallin, A., Johannessen, L., Cani, P., Marbehant, C., Essaghir, A. et al. (2007). Journal of Lipid Research, vol. 48, ss. 1628-1636 DOI
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.
Li, L., Asteriou, T., Bernert, B., Heldin, C., Heldin, P. (2007). Biochemical Journal, vol. 404, ss. 327-336 DOI
An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.
Looman, C., Sun, T., Yu, Y., Zieba, A., Åhgren, A. et al. (2007). International Journal of Developmental Biology, vol. 51, ss. 361-370 DOI
In Situ Identification of Genes Regulated Specifically in Fibroblasts of Human Basal Cell Carcinoma.
Micke, P., Kappert, K., Ohshima, M., Sundquist, C., Scheidl, S. et al. (2007). Journal of Investigative Dermatology, vol. 127, ss. 1516-1523 DOI
Notch signaling is necessary for epithelial growth arrest by TGF-beta.
Niimi, H., Pardali, K., Vanlandewijck, M., Heldin, C., Moustakas, A. (2007). Journal of Cell Biology, vol. 176, ss. 695-707 DOI
Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma.
Suzuki, S., Heldin, C., Heuchel, R. (2007). BMC Cancer, vol. 7, ss. 224- DOI
Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.
Valcourt, U., Thuault, S., Pardali, K., Heldin, C., Moustakas, A. (2007). Molecular Oncology, vol. 1, ss. 55-71 DOI
c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts.
Amagasaki, K., Kaneto, H., Heldin, C., Lennartsson, J. (2006). Journal of Biological Chemistry, . vol. 281, ss. 22173-22179 DOI
The gene expression profile of PDGF-treated neural stem cells corresponds to partially differentiated neurons and glia.
Demoulin, J., Enarsson, M., Larsson, J., Essaghir, A., Heldin, C. et al. (2006). Growth Factors, vol. 24, ss. 184-196 DOI
Tyrosine kinases, receptor-linked - platelet-derived growth factor receptors.
Heldin, C. (2006). I K. Watling (red.) Sigma-RBI Handbook of Receptor Classification and Signal Transduction, . ss. 292-294
A new twist in Smad signaling.
Heldin, C., Moustakas, A. (2006). Developmental Cell, vol. 10, ss. 685-686 DOI
Characterization of an imatinib-sensitive subset of high-grade human glioma cultures.
Hägerstrand, D., Hesselager, G., Achterberg, S., Wickenberg Bolin, U., Kowanetz, M. et al. (2006). Oncogene, vol. 25, ss. 4913-4922 DOI
Highly Active Antiretroviral Therapy Attenuates Re-Endothelialization and Alters Neointima Formation in the Rat Carotid Artery After Balloon Injury.
Kappert, K., Leppänen, O., Paulsson, J., Furuhashi, M., Carlsson, M. et al. (2006). Journal of Acquired Immune Deficiency Syndromes, vol. 43, ss. 383-392 DOI
Loss of T-Cell Protein Tyrosine Phosphatase Induces Recycling of the Platelet-derived Growth Factor (PDGF) beta-Receptor but Not the PDGF {alpha}-Receptor.
Karlsson, S., Kowanetz, K., Sandin, Å., Persson, C., Östman, A. et al. (2006). Molecular Biology of the Cell, vol. 17, ss. 4846-4855 DOI
The mechanism of nuclear export of smad3 involves exportin 4 and Ran.
Kurisaki, A., Kurisaki, K., Kowanetz, M., Sugino, H., Yoneda, Y. et al. (2006). Molecular and Cellular Biology, vol. 26, ss. 1318-1332 DOI
Alix Facilitates the Interaction between c-Cbl and Platelet-derived Growth Factor beta-Receptor and Thereby Modulates Receptor Down-regulation.
Lennartsson, J., Wardega, P., Engström, U., Hellman, U., Heldin, C. (2006). Journal of Biological Chemistry, vol. 281, ss. 39152-39158 DOI
Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44.
Li, L., Heldin, C., Heldin, P. (2006). Journal of Biological Chemistry, vol. 281, ss. 26512-26519 DOI
Deletion of exon I of SMAD7 in mice results in altered B cell responses.
Li, R., Rosendahl, A., Brodin, G., Cheng, A., Åhgren, A. et al. (2006). Journal of Immunology, vol. 176, ss. 6777-6784
The Smad family.
ten Dijke, P., Heldin, C. (2006). I P. ten Dijke and C.-H. Heldin (red.) Smad Signal Transduction, Dordrecht, The Netherlands: Springer. ss. 1-13
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.
Thuault, S., Valcourt, U., Petersen, M., Manfioletti, G., Heldin, C. et al. (2006). Journal of Cell Biology, vol. 174, ss. 175-183 DOI
Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells.
Valdimarsdottir, G., Goumans, M., Itoh, F., Itoh, S., Heldin, C. et al. (2006). BMC Cell Biology, vol. 7, ss. 16- DOI
Bone morphogenetic proteins and their receptors.
van Bezooijen, R., Heldin, C., ten Dijke, P. (2006). I Encyclopedia of Life Sciences Chichester: John Wiley & Sons, Ltd.. DOI
TGF beta 1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner.
Zhang, S., Ekman, M., Thakur, N., Bu, S., Davoodpour, P. et al. (2006). Cell Cycle, vol. 5, ss. 2787-2795
TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
Dubrovska, A., Kanamoto, T., Lomnytska, M., Heldin, C., Volodko, N. et al. (2005). Oncogene, vol. 24, ss. 2289-2297 DOI
Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis.
Edlund, S., Lee, S., Grimsby, S., Zhang, S., Aspenström, P. et al. (2005). Molecular and Cellular Biology, vol. 25, ss. 1475-1488 DOI
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
Li, X., Tjwa, M., Moons, L., Fons, P., Noel, A. et al. (2005). Journal of Clinical Investigation, vol. 115, ss. 118-127 DOI
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.
Morén, A., Imamura, T., Miyazono, K., Heldin, C., Moustakas, A. (2005). Journal of Biological Chemistry, vol. 280, ss. 22115-22123 DOI
Non-Smad TGF-{beta} signals.
Moustakas, A., Heldin, C. (2005). Journal of Cell Science, vol. 118, ss. 3573-3584 DOI
Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1.
Pardali, K., Kowanetz, M., Heldin, C., Moustakas, A. (2005). Journal of Cellular Physiology, . vol. 204, ss. 260-272 DOI
Regulation of chemotaxis by the cytoplasmic domain of tissue factor.
Siegbahn, A., Johnell, M., Sorensen, B., Petersen, L., Heldin, C. (2005). Thrombosis and Haemostasis, vol. 93, ss. 27-34 DOI
The balance between acetylation and deacetylation controls Smad7 stability.
Simonsson, M., Heldin, C., Ericsson, J., Grönroos, E. (2005). Journal of Biological Chemistry, . vol. 280, ss. 21797-21803 DOI
Platelet-Derived Growth Factor:: Normal Function, Role in Disease, and Application of PDGF Antagonists.
Sjöblom, T., Pietras, K., Östman, A., Heldin, C. (2005). I D. Fabbro and F. McCormick (red.) Protein Tyrosine Kinases, Totowa, NJ: Humana Press. ss. 161-186 DOI
Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription.
Stasyk, T., Dubrovska, A., Lomnytska, M., Yakymovych, I., Wernstedt, C. et al. (2005). Molecular Biology of the Cell, vol. 16, ss. 4765-4780 DOI
TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition.
Valcourt, U., Kowanetz, M., Niimi, H., Heldin, C., Moustakas, A. (2005). Molecular Biology of the Cell, . vol. 16, ss. 1987-2002 DOI
Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail.
Chiara, F., Bishayee, S., Heldin, C., Demoulin, J. (2004). Journal of Biological Chemistry, vol. 279, ss. 19732-19738 DOI
A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.
Chiara, F., Goumans, M., Forsberg, H., Åhgrén, A., Rasola, A. et al. (2004). Journal of Biological Chemistry, vol. 279, ss. 42516-42527 DOI
Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.
Demoulin, J., Ericsson, J., Kallin, A., Rorsman, C., Rönnstrand, L. et al. (2004). Journal of Biological Chemistry, vol. 279, ss. 35392-35402 DOI
Smad7 is required for TGF-ß-induced activation of the small GTPase Cdc42.
Edlund, S., Landström, M., Heldin, C., Aspenström, P. (2004). Journal of Cell Science, . vol. 117, ss. 1835-1847 DOI
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.
Furuhashi, M., Sjöblom, T., Abramsson, A., Ellingsen, J., Micke, P. et al. (2004). Cancer Research, vol. 64, ss. 2725-2733 DOI
High interstitial fluid pressure - an obstacle in cancer therapy..
Heldin, C., Rubin, K., Pietras, K., Östman, A. (2004). Nat Rev Cancer, vol. 4, ss. 806-13
Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor.
Kallin, A., Demoulin, J., Nishida, K., Hirano, T., Rönnstrand, L. et al. (2004). Journal of Biological Chemistry, . vol. 279, ss. 17897-17904 DOI
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
Kowanetz, K., Crosetto, N., Haglund, K., Schmidt, M., Heldin, C. et al. (2004). Journal of Biological Chemistry, vol. 279, ss. 32786-32795 DOI
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein.
Kowanetz, M., Valcourt, U., Bergström, R., Heldin, C., Moustakas, A. (2004). Molecular and Cellular Biology, . vol. 24, ss. 4241-4254 DOI
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits..
Leppänen, O., Rutanen, J., Hiltunen, M., Rissanen, T., Turunen, M. et al. (2004). Circulation, vol. 109, ss. 1140-6
Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases.
Persson, C., Sjöblom, T., Groen, A., Kappert, K., Engström, U. et al. (2004). Proceedings of the National Academy of Sciences of the United States of America, vol. 101, ss. 1886-1891 DOI
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Persson, C., Sävenhed, C., Bourdeau, A., Tremblay, M., Markova, B. et al. (2004). Molecular and Cellular Biology, vol. 24, ss. 2190-2201 DOI
Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice.
Sjöblom, T., Yakymovych, I., Heldin, C., Östman, A., Souchelnytskyi, S. (2004). European Journal of Cancer, vol. 40, ss. 267-274 DOI
Smad2 phosphorylation by type I receptor: contribution of arginine 462 and cysteine 463 In the C terminus of Smad2 for specificity.
Yakymovych, I., Heldin, C., Souchelnytskyi, S. (2004). Journal of Biological Chemistry, vol. 279, ss. 35781-35787 DOI
Platelet-derived growth factor (PDGF).
Östman, A., Heldin, C. (2004). I Martini, Luciano (red.) Encyclopedia of Endocrine Diseases, London: Elsevier. ss. 690-696
Transforming growth factor-beta1-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.
Edlund, S., Bu, S., Schuster, N., Aspenström, P., Heuchel, R. et al. (2003). Molecular Biology of the Cell, . vol. 14, ss. 529-544 DOI
Effect of transforming growth factor-beta on calcium homeostasis inprostate carcinoma cells..
Gizatullina, Z., Grapengiesser, E., Shabalina, I., Nedergaard, J., Heldin, C. et al. (2003). Biochem Biophys Res Commun, vol. 304, ss. 643-
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses.
Itoh, S., Thorikay, M., Kowanetz, M., Moustakas, A., Itoh, F. et al. (2003). Journal of Biological Chemistry, vol. 278, ss. 3751-3761 DOI
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation.
Kurisaki, K., Kurisaki, A., Valcourt, U., Terentiev, A., Pardali, K. et al. (2003). Molecular and Cellular Biology, vol. 23, ss. 4494-4510 DOI
Differential ubiquitination defines the functional status of the tumor suppressor Smad4.
Morén, A., Hellman, U., Inada, Y., Imamura, T., Heldin, C. et al. (2003). Journal of Biological Chemistry, vol. 278, ss. 33571-33582 DOI
PDGF receptors as cancer drug targets..
Pietras, K., Sjöblom, T., Rubin, K., Heldin, C., Östman, A. (2003). Cancer Cell, vol. 3, ss. 439-
STI571 enhances the therapeutic index of epothilone B by a tumor-selectiveincrease of drug uptake..
Pietras, K., Stumm, M., Hubert, M., Buchdunger, E., Rubin, K. et al. (2003). Clin Cancer Res, vol. 9, ss. 3779-
Transforming growth factor-beta-induced mobilization of actin cytoskeleton required signaling by small GTPases Cdc42 and RhoA.
Edlund, S., Landström, M., Heldin, C., Aspenström, P. (2002). Molecular Biology of the Cell, . vol. 13, ss. 902-914 DOI
Bone morphogenetic protein-7 (OP1) and transforming growth factor-beta1 modulate 1,25(OH)2-vitamin D3-induced differentiation of human osteoblasts.
Eichner, A., Brock, J., Heldin, C., Souchelnytskyi, S. (2002). Experimental Cell Research, vol. 275, ss. 132-142 DOI
SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor.
Ekman, S., Kallin, A., Engström, U., Heldin, C., Rönnstrand, L. (2002). Oncogene, . vol. 21, ss. 1870-1875 DOI
Control of Smad7 stability by competition between acetylation and ubiquitination.
Grönroos, E., Hellman, U., Heldin, C., Ericsson, J. (2002). Molecular Cell, vol. 10, ss. 483-493 DOI
Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair.
Kanamoto, T., Hellman, U., Heldin, C., Souchelnytskyi, S. (2002). EMBO Journal, vol. 21, ss. 1219-1230 DOI
Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration.
Palumbo, R., Gaetano, C., Antonini, A., Pompilio, G., Bracco, E. et al. (2002). Arteriosclerosis, Thrombosis and Vascular Biology, vol. 22, ss. 405-411 DOI
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.
Pietras, K., Rubin, K., Sjöblom, T., Buchdunger, E., Sjöquist, M. et al. (2002). Cancer Research, vol. 62, ss. 5476-5484
BRCA2 and Smad3 synergize in regulation of gene transcription.
Preobrazhenska, O., Yakymovych, M., Kanamoto, T., Yakymovych, I., Stoika, R. et al. (2002). Oncogene, vol. 21, ss. 5660-5664
Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation.
Rosendahl, A., Pardali, E., Speletas, M., ten Dijke, P., Heldin, C. et al. (2002). American Journal of Respiratory Cell and Molecular Biology, vol. 27, ss. 160-169 DOI
Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF beta type I receptor kinase.
Yakymovych, I., Engström, U., Grimsby, S., Heldin, C., Souchelnytskyi, S. (2002). Biochemistry, vol. 41, ss. 11000-11007 DOI
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Bergsten, E., Uutela, M., Li, X., Pietras, K., Östman, A. et al. (2001). Nature Cell Biology, . vol. 3, ss. 512-516 DOI
Platelet-derived growth factor.
Heldin, C. (2001). I Encyclopedic Reference of Cancer, . ss. 701-703
Signal transduction: multiple pathways, multiple options for therapy.
Heldin, C. (2001). Stem Cells, vol. 19, ss. 295-303 DOI
Signal transduction mechanisms for members of the TGF-beta superfamily.
Heldin, C., Moustakas, A., Souchelnytskyi, S., Itoh, S., ten Dijke, P. (2001). I TGF-beta and Related Cytokines in Inflammation, . ss. 11-40
Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner.
Kurisaki, A., Kose, S., Yoneda, Y., Heldin, C., Moustakas, A. (2001). Molecular Biology of the Cell, vol. 12, ss. 1079-1091 DOI
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors..
Pietras, K., Östman, A., Sjöquist, M., Buchdunger, E., Reed, R. et al. (2001). Cancer Res, vol. 61, ss. 2929-
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors..
Pietras, K., Östman, A., Sjöquist, M., Buchdunger, E., Reed, R. et al. (2001). Cancer Research, . vol. 61, ss. 2929-2934
Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation.
Pulaski, L., Landström, M., Heldin, C., Souchelnytskyi, S. (2001). Journal of Biological Chemistry, vol. 276, ss. 14344-14349 DOI
Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation.
Rosendahl, A., Checchin, D., Fehniger, T., ten Dijke, P., Heldin, C. et al. (2001). American Journal of Respiratory Cell and Molecular Biology, vol. 25, ss. 60-68 DOI
Mechanisms of platelet-derived growth factor-induced chemotaxis.
Rönnstrand, L., Heldin, C. (2001). International Journal of Cancer, vol. 91, ss. 757-762
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis..
Sjöblom, T., Shimizu, A., O'Brien, K., Pietras, K., Dal Cin, P. et al. (2001). Cancer Res, vol. 61, ss. 5778-83
Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases.
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Regulation of Smad signaling by protein kinase C.
Yakymovych, I., ten Dijke, P., Heldin, C., Souchelnytskyi, S. (2001). The FASEB Journal, vol. 15, ss. 553-555 DOI
Involvement of platelet-derived growth factor in disease: development of specific antagonists.
Östman, A., Heldin, C. (2001). Advances in Cancer Research, vol. 80, ss. 1-38 DOI
Platelet-Derived Growth Factor-Mediated Signaling through the Shb Adaptor Protein: Effects on Cytoskeletal Organization.
Hooshmand-Rad, R., Lu, L., Heldin, C., Claesson-Welsh, L., Welsh, M. (2000). Experimental Cell Research, vol. 257, ss. 245-254 DOI
Smad7 mediates TGF-beta-induced apoptosis in prostatic carcinoma cells..
Landström, M., Heldin, N., Bu, S., Hermansson, A., Itoh, S. et al. (2000). Current Biol., vol. 10, ss. 535-
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor..
Li, X., Pontén, A., Aase, K., Karlsson, L., Abramsson, A. et al. (2000). Nat Cell Biol, vol. 2, ss. 302-9
Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis..
Siegbahn, A., Johnell, M., Rorsman, C., Ezban, M., Heldin, C. et al. (2000). Blood, vol. 96, ss. 3452-8
Mechanism of action and in vivo role of platelet-derived growth factor.
Heldin, C., Westermark, B. (1999). Physiological Reviews, vol. 79, ss. 1283-1316
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling.
Heuchel, R., Berg, A., Tallquist, M., Åhlén, K., Reed, R. et al. (1999). Proc Natl Acad Sci U S A, vol. 96, ss. 11410-5
Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.
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Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
Afrakhte, M., Morén, A., Jossan, S., Itoh, S., Sampath, K. et al. (1998). Biochemical and Biophysical Research Communications - BBRC, vol. 249, ss. 505-11 DOI
Phosphorylation of a 72-kDa protein in PDGF-stimulated cells which forms complex with c-Crk, c-Fyn and Eps15..
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Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.
Hansen, K., Johnell, M., Siegbahn, A., Rorsman, C., Engström, U. et al. (1996). EMBO Journal, vol. 15, ss. 5299-5313
Luteal failure in transgenic mice carrying a PDGF dominant-negative mutant/GH hybrid transgene.
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Expression of transforming growth factor b1, b2, b3 in neuroendocrine tumors of the digestive system.
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