Publikationer

Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence.
Abdalaal, H., Pundir, S., Ge, X., Sanyal, S., Näsvall, J. (2020). Molecular biology and evolution, . vol. 37, ss. 2918-2930 DOI
Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA.
Knöppel, A., Andersson, D., Näsvall, J. (2020). Frontiers in Microbiology, vol. 11 DOI
Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence.
Lundin, E., Näsvall, J., Andersson, D. (2020). Frontiers in Microbiology, vol. 11 DOI
Selection for novel metabolic capabilities in Salmonella enterica.
Warsi, O., Lundin, E., Lustig, U., Näsvall, J., Andersson, D. (2019). Evolution, vol. 73, ss. 990-1000 DOI
Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica.
Knöppel, A., Knopp, M., Albrecht, L., Lundin, E., Lustig, U. et al. (2018). Frontiers in Microbiology, vol. 9 DOI
Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA.
Lundin, E., Tang, P., Guy, L., Näsvall, J., Andersson, D. (2018). Molecular biology and evolution, vol. 35, ss. 704-718 DOI
Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica.
Stern, A., Van der Verren, S., Kanchugal Puttaswamy, S., Näsvall, J., Gutiérrez-de-Terán, H. et al. (2018). Journal of Biological Chemistry, vol. 293, ss. 11481-11490 DOI
Evolution of antibiotic resistance without antibiotic exposure.
Knöppel, A., Näsvall, J., Andersson, D. (2017). Antimicrobial Agents and Chemotherapy, vol. 61 DOI
Structural and functional innovations in the real-time evolution of new (βα)₈ barrel enzymes.
Newton, M., Guo, X., Söderholm, A., Näsvall, J., Lundström, P. et al. (2017). Proceedings of the National Academy of Sciences of the United States of America, vol. 114, ss. 4727-4732 DOI
Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes.
Näsvall, J. (2017). PLOS ONE, vol. 12 DOI
Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria.
Näsvall, J., Knöppel, A., Andersson, D. (2017). Nucleic Acids Research, . vol. 45 DOI Ladda ner fulltext
Compensating the fitness costs of synonymous mutations.
Knöppel, A., Näsvall, J., Andersson, D. (2016). Molecular biology and evolution, vol. 33, ss. 1461-1477 DOI
Evolution of New Functions De Novo and from Preexisting Genes.
Andersson, D., Jerlström-Hultqvist, J., Näsvall, J. (2015). Cold Spring Harbor Perspectives in Biology, vol. 7 DOI
Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase.
Chen, Y., Näsvall, J., Wu, S., Andersson, D., Selmer, M. (2015). Acta Crystallographica Section D, vol. 71, ss. 2267-2277 DOI
Two-step Ligand Binding in a (βα)8 Barrel Enzyme: Substrate-bound Structures Shed New Light on the Catalytic Cycle of HisA.
Söderholm, A., Guo, X., Newton, M., Evans, G., Näsvall, J. et al. (2015). Journal of Biological Chemistry, vol. 290, ss. 24657-24668 DOI
Minor Fitness Costs in an Experimental Model of Horizontal Gene Transfer in Bacteria.
Knöppel, A., Lind, P., Lustig, U., Näsvall, J., Andersson, D. (2014). Molecular biology and evolution, vol. 31, ss. 1220-1227 DOI
Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence.
Näsvall, J., Sun, L., Roth, J., Andersson, D. (2012). Science, vol. 338, ss. 384-387 DOI
Activation of cryptic aminoglycoside resistance in Salmonella enterica.
Koskiniemi, S., Pränting, M., Gullberg, E., Näsvall, J., Andersson, D. (2011). Molecular Microbiology, vol. 80, ss. 1464-1478 DOI

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Publikationer

Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence.

Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA.

Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence.

Selection for novel metabolic capabilities in Salmonella enterica.

Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica.

Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA.

Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica.

Evolution of antibiotic resistance without antibiotic exposure.

Structural and functional innovations in the real-time evolution of new (βα)₈ barrel enzymes.

Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes.

Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria.

Compensating the fitness costs of synonymous mutations.

Evolution of New Functions De Novo and from Preexisting Genes.

Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase.

Two-step Ligand Binding in a (βα)8 Barrel Enzyme: Substrate-bound Structures Shed New Light on the Catalytic Cycle of HisA.

Minor Fitness Costs in an Experimental Model of Horizontal Gene Transfer in Bacteria.

Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence.

Activation of cryptic aminoglycoside resistance in Salmonella enterica.