Publikationer
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
(2023). Journal of Medicinal Chemistry, . vol. 66, ss. 1380-1425 DOI -
Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.
(2022). Clinical Microbiology and Infection, . vol. 28, ss. 1367-1374 DOI -
Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections.
(2022). Frontiers in Microbiology, . vol. 13 DOI -
Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents.
(2022). Frontiers in Microbiology, . vol. 13 DOI -
Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes.
(2022). Genome Biology and Evolution, . vol. 14 DOI -
Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria.
(2022). Molecular biology and evolution, . vol. 39 DOI -
Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2).
(2022). ACS Infectious Diseases, . vol. 8, ss. 482-498 DOI -
Genetic Architecture and Fitness of Bacterial Interspecies Hybrids.
(2021). Molecular biology and evolution, . vol. 38, ss. 1472-1481 DOI -
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
(2021). Clinical Microbiology and Infection, . vol. 27, ss. 1315-1321 DOI -
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
(2021). EBioMedicine, . vol. 73 DOI -
Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation.
(2021). European Journal of Medicinal Chemistry, . vol. 224 DOI -
Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections.
(2021). Proceedings of the National Academy of Sciences of the United States of America, . vol. 118 DOI -
Expression of the qepA1 gene is induced under antibiotic exposure.
(2021). Journal of Antimicrobial Chemotherapy, . vol. 76, ss. 1433-1440 DOI -
Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response.
(2021). Journal of Antimicrobial Chemotherapy, . vol. 76, ss. 606-615 DOI -
Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella.
(2021). mBio, . vol. 12 DOI -
ENABLE: an engine for European antibacterial drug discovery and development.
(2021). Nature reviews. Drug discovery, vol. 20, ss. 407-408 DOI -
Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli.
(2021). Journal of Antimicrobial Chemotherapy, . vol. 76, ss. 77-83 DOI -
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
(2021). Clinical Pharmacology and Therapeutics, . vol. 109, ss. 1063-1073 DOI -
Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins.
(2021). Journal of Antimicrobial Chemotherapy, . vol. 76, ss. 1441-1447 DOI -
The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation.
(2020). PLOS Genetics, . vol. 16 DOI -
Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli.
(2020). Molecular biology and evolution, . vol. 37, ss. 1637-1646 DOI -
Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene.
(2020). Proceedings of the National Academy of Sciences of the United States of America, . vol. 117, ss. 3185-3191 DOI -
Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues.
(2020). Bioorganic & Medicinal Chemistry, . vol. 28 DOI -
Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria.
(2020). ACS Chemical Biology, . vol. 15, ss. 2937-2944 DOI -
Synthesis of New N-Acyl-1,2,3-triazole Chalcones and Determination of Their Antibacterial Activity.
(2020). Doklady. Chemistry, . vol. 492, ss. 89-92 DOI -
Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes.
(2019). Molecular biology and evolution, vol. 36, ss. 1990-2000 DOI -
Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella.
(2019). Bio-protocol, . vol. 9 DOI -
In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.
(2019). Journal of Antimicrobial Chemotherapy, . vol. 74, ss. 944-952 DOI -
Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella.
(2018). Molecular Microbiology, . vol. 108, ss. 697-710 DOI -
Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB..
(2018). Scientific Reports, vol. 8 DOI -
Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella.
(2018). mBio, . vol. 9 DOI -
Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli.
(2018). Journal of Antimicrobial Chemotherapy, vol. 73, ss. 3285-3292 DOI -
Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli.
(2018). Journal of Antimicrobial Chemotherapy, vol. 73, ss. 348-352 DOI -
Methods to determine mutational trajectories after experimental evolution of antibiotic resistance..
(2018). Methods in Molecular Biology, New York: Humana Press. vol. 1736, ss. 95-103 DOI -
Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.
(2018). Journal of Medicinal Chemistry, vol. 61, ss. 3565-3581 DOI -
Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli.
(2018). International Journal of Antimicrobial Agents, vol. 51, ss. 399-406 DOI -
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
(2018). Molecular Cell, . vol. 70, ss. 83-94 DOI -
Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase.
(2018). European Journal of Medicinal Chemistry, vol. 157, ss. 1346-1360 DOI -
Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium.
(2018). Frontiers in Microbiology, vol. 9 DOI -
Selection and Transmission of Antibiotic-Resistant Bacteria.
(2017). Microbiology Spectrum, vol. 5 5 DOI -
Bacterial pathogens, antibiotics and antibiotic resistance: Editorial.
(2017). FEMS Microbiology Reviews, vol. 41, ss. 450-452 DOI -
Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance.
(2017). MICROBIAL CELL, vol. 4 4, ss. 275 275-277 277 DOI -
Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus.
(2017). mBio, . vol. 8 DOI -
Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).
(2017). Bioorganic & Medicinal Chemistry, vol. 25, ss. 897-911 DOI -
Elongation Factors: Translation.
(2017). I Reference Module in Life Sciences . DOI -
Environmental and genetic modulation of the phenotypic expression of antibiotic resistance.
(2017). FEMS Microbiology Reviews, vol. 41, ss. 374-391 DOI -
Evolutionary Trajectories to Antibiotic Resistance.
(2017). Annual Review of Microbiology, vol. 71, ss. 579-596 DOI -
Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli.
(2017). Molecular biology and evolution, vol. 34, ss. 1029-1039 DOI -
Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs.
(2017). mBio, vol. 8 DOI -
Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data.
(2017). Journal of Antimicrobial Chemotherapy, . vol. 72, ss. 3108-3116 DOI -
The processive kinetics of gene conversion in bacteria.
(2017). Molecular Microbiology, . vol. 104, ss. 752-760 DOI -
Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice.
(2017). Frontiers in Immunology, . vol. 8 DOI -
Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects.
(2017). Journal of Antimicrobial Chemotherapy, . vol. 72, ss. 75-84 DOI -
Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs.
(2017). Journal of Antimicrobial Chemotherapy, vol. 2, ss. 3016-3024 DOI -
Mechanisms and consequences of bacterial resistance to antimicrobial peptides.
(2016). Drug resistance updates, vol. 26, ss. 43-57 DOI -
Autoregulation of the tufB operon in Salmonella.
(2016). Molecular Microbiology, . vol. 100, ss. 1004-1016 DOI -
The Selective Advantage of Synonymous Codon Usage Bias in Salmonella.
(2016). PLOS Genetics, vol. 12 DOI -
Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.
(2016). Bioorganic & Medicinal Chemistry Letters, vol. 26, ss. 4179-4183 DOI -
Using the power of genetic suppressors to probe the essential functions of RNase E.
(2016). Current Genetics, vol. 62, ss. 53-57 DOI -
Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain.
(2016). Journal of Antimicrobial Chemotherapy, . vol. 71, ss. 324-332 DOI -
Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis.
(2015). Journal of Antimicrobial Chemotherapy, . vol. 70, ss. 680-685 DOI -
Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms.
(2015). Nature reviews genetics, vol. 16, ss. 459-471 DOI -
A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants.
(2015). Journal of Antimicrobial Chemotherapy, vol. 70, ss. 3051-3060 DOI -
Turnover of mRNAs is one of the essential functions of RNase E.
(2015). Molecular Microbiology, vol. 98, ss. 34-45 DOI -
Genetics: Location affects sporulation.
(2015). Nature, vol. 525, ss. 42-43 DOI -
Microbiological effects of sublethal levels of antibiotics.
(2014). Nature Reviews Microbiology, vol. 12, ss. 465-478 DOI -
Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu.
(2014). PLOS ONE, vol. 9, ss. e90486- DOI -
Acetate availability and utilization supports the growth of mutant sub-populations on aging bacterial colonies.
(2014). PLOS ONE, vol. 9, ss. e109255- DOI -
Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli.
(2014). Clinical Microbiology and Infection, vol. 20, ss. O267-O273 DOI -
Selection and Evolution of Resistance to Antimicrobial Drugs.
(2014). IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, vol. 66, ss. 521-529 DOI -
Discovery and preclinical development of new antibiotics.
(2014). Upsala Journal of Medical Sciences, vol. 119, ss. 162-169 DOI -
Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility.
(2014). International Journal of Antimicrobial Agents, vol. 44, ss. 354-357 DOI -
Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates.
(2013). Journal of Antimicrobial Chemotherapy, . vol. 68, ss. 2493-2497 DOI -
Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution.
(2013). Antibiotics, . vol. 2, ss. 206-216 DOI -
Evolution of antibiotic resistance at non-lethal drug concentrations..
(2012). Drug resistance updates, vol. 15, ss. 162-172 DOI -
Fitness-compensatory mutations in rifampicin-resistant RNA polymerase.
(2012). Molecular Microbiology, . vol. 85, ss. 142-151 DOI -
Selection of resistance at lethal and non-lethal antibiotic concentrations.
(2012). Current Opinion in Microbiology, vol. 15, ss. 555-560 DOI -
Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic.
(2012). Journal of Antimicrobial Chemotherapy, vol. 67, ss. 1325-1332 DOI -
Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria.
(2012). PLOS ONE, vol. 7, ss. e42639- DOI -
Persistence of antibiotic resistance in bacterial populations.
(2011). FEMS Microbiology Reviews, vol. 35, ss. 901-911 DOI -
Selection of Resistant Bacteria at Very Low Antibiotic Concentrations.
(2011). PLoS pathogens, vol. 7, ss. e1002158- DOI -
Temperature-sensitive mutants of RNase E in Salmonella enterica.
(2011). Journal of Bacteriology, vol. 193, ss. 6639-6650 DOI -
Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus.
(2011). PLOS ONE, vol. 6, ss. e28366- DOI -
Can phylogenetic type predict resistance development?.
(2011). Journal of Antimicrobial Chemotherapy, vol. 66, ss. 778-787 DOI -
Can phylogenetic type predict resistance development?.
(2011). Journal of Antimicrobial Chemotherapy, vol. 66, ss. 778-787 DOI -
Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a Clinical Staphylococcus aureus Strain with a Small-Colony-Variant Phenotype in an In Vitro Model of THP-1 Macrophages and an In Vivo Mouse Peritonitis Model.
(2011). Antimicrobial Agents and Chemotherapy, vol. 55, ss. 1443-1452 DOI -
Antibiotic resistance and its cost: is it possible to reverse resistance?.
(2010). Nature Reviews Microbiology, vol. 8, ss. 260-271 DOI -
The origin of mutants under selection: Interactions of mutation, growth and selection.
(2010). I Böck et al (red.) EcoSal - Escherichia coli and Salmonella: cellular and molecular biology Washington, DC: ASM Press. DOI -
Biological roles of translesion synthesis DNA polymerases in eubacteria.
(2010). Molecular Microbiology, vol. 77, ss. 540-548 DOI -
Adventures with mutation and selection in beehive and cow country.
(2010). I Maloy, S., Hughes, K.T. and Casadesus, J (red.) The Lure of Bacterial Genetics, Washington, DC: ASM Press. ss. 245-253 -
Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium.
(2010). I Gillespie, Stephen H. & McHugh, Timothy D. (red.) Antibiotic Resistance Protocols, . ss. 105-112 DOI -
Effect of the translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimurium.
(2010). Genetics, vol. 185, ss. 783-795 DOI -
Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity.
(2010). I Gillespie, Stephen H. & McHugh, Timothy D. (red.) Antibiotic Resistance Protocols, . ss. 95-103 DOI -
Gene amplification and adaptive evolution in bacteria.
(2009). Annual Review of Genetics, vol. 43, ss. 167-195 DOI -
Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus.
(2009). Antimicrobial Agents and Chemotherapy, vol. 53, ss. 2059-2065 DOI -
Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness.
(2009). PLoS Pathogens, vol. 5, ss. e1000541- DOI -
Effects of antibiotic resistance on bacterial fitness, virulence and transmission.
(2008). I Baquero, Fernando Nombela, Cesar Cassell, Gail H. (red.) Evolutionary biology of bacterial and fungal pathogens, Washington DC: ASM Press. ss. 307-318 -
Mutants of the RNA-processing enzyme RNase E reverse the extreme slow-growth phenotype caused by a mutant translation factor EF-Tu.
(2008). Molecular Microbiology, vol. 70, ss. 1194-1209 DOI -
Comparative genomics and the development of novel antimicrobials.
(2008). I Comparative genomics: basic and applied research, . ss. 177-192 DOI -
Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus.
(2008). Antimicrobial Agents and Chemotherapy, vol. 52, ss. 4017-4022 DOI -
Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis.
(2008). Proceedings of the National Academy of Sciences of the United States of America, . vol. 105, ss. 11863-11868 DOI -
Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
(2007). Antimicrobial Agents and Chemotherapy, vol. 51, ss. 4438-4446 DOI -
Dose-related selection of fluoroquinolone-resistant Escherichia coli.
(2007). Journal of Antimicrobial Chemotherapy, vol. 60, ss. 795-801 DOI -
Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration.
(2006). Journal of Antimicrobial Chemotherapy, vol. 57, ss. 1116-1121 DOI -
Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli.
(2006). Antimicrobial Agents and Chemotherapy, vol. 50, ss. 3454-3456 DOI -
Biological consequences for bacteria of homologous recombination.
(2005). I Peter Mullany (red.) The Dynamic Bacterial Genome, . ss. 351-384 DOI -
Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.
(2005). Antimicrobial Agents and Chemotherapy, vol. 49, ss. 2343-2351 DOI -
Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes.
(2005). Antimicrobial Agents and Chemotherapy, vol. 49, ss. 3435-3441 DOI -
Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics.
(2005). FEMS Microbiology Letters, vol. 247, ss. 215-220 DOI -
Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli.
(2005). Journal of Antimicrobial Chemotherapy, vol. 55, ss. 938-943 DOI -
Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium.
(2004). Journal of Molecular Biology, vol. 338, ss. 463-467 DOI -
Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress.
(2004). Antimicrobial Agents and Chemotherapy, vol. 48, ss. 3877-3883 DOI -
Exploiting genomics, genetics and chemistry to combat antibiotic resistance.
(2003). Nature reviews genetics, vol. 4, ss. 432-441 DOI -
Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary tract infections.
(2003). Antimicrobial Agents and Chemotherapy, vol. 47, ss. 3222-3232 DOI -
Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction.
(2003). Antimicrobial Agents and Chemotherapy, vol. 47, ss. 3743-3749 DOI -
The physiological cost of antibiotic resistance.
(2003). Recent research developments in microbiology, Trivandrum, India: Research Signpost. vol. 7, ss. 607-629 -
Target alterations mediating antibiotic resistance.
(2001). I Diarmaid Hughes & Dan I Andersson (red.) Antibiotic Development and Resistance, . ss. 23-36 -
Antibiotic Development and Resistance.
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Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus.
(2001). Molecular Microbiology, . vol. 40, ss. 433-439 DOI -
Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance.
(2000). Science, . vol. 287, ss. 1479-1482 DOI -
Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions.
(2000). Journal of Molecular Biology, . vol. 297, ss. 355-364 DOI -
Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes.
(2000). Genome Biology, vol. 1, ss. 0006.1-0006.8 DOI -
Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site.
(2000). Journal of Molecular Biology, vol. 303, ss. 593-603 DOI -
Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp.
(2000). Molecular Microbiology, . vol. 37, ss. 98-107 DOI -
Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium.
(1999). Molecular Microbiology, . vol. 31, ss. 53-58 DOI -
Impact of homologous recombination and gene conversion on genomic organisation and stability.
(1999). I Robert L. Charlebois (red.) Organization of the prokaryotic genome, . ss. 109-128 -
Antibiotikaresistens här för att stanna?.
(1998). Läkartidningen, vol. 95, ss. 3940-3944 -
Virulence of antibiotic-resistant Salmonella typhimurium.
(1998). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, . vol. 95, ss. 3949-3953 -
Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates.
(1997). JOURNAL OF BACTERIOLOGY, . vol. 179, ss. 6688-6691 -
Mutants of EF-Tu defective in binding aminoacyl-tRNA.
(1996). FEBS Letters, vol. 382, ss. 297-303 DOI -
Homologous recombination between the tuf genes of Salmonella typhimurium.
(1996). Journal of Molecular Biology, vol. 260, ss. 506-522 DOI -
Muller's ratchet decreases fitness of a DNA-based microbe.
(1996). Proceedings of the National Academy of Sciences of the United States of America, vol. 93, ss. 906-907 -
The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants.
(1996). JOURNAL OF MOLECULAR BIOLOGY, . vol. 258, ss. 420-432 -
Limitations of translational accuracy.
(1996). I Escherichia coli and Salmonella, . ss. 979-1004 -
tRNA-ribosome interactions.
(1995). Biochemistry and Cell Biology, vol. 73, ss. 1049-1054 -
A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance.
(1995). Nucleic Acids Research, vol. 23, ss. 464-466 -
Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP.
(1994). FEBS Letters, vol. 352, ss. 118-122 DOI -
Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium.
(1994). Gene, vol. 143, ss. 55-59 DOI -
Ternary complex-ribosome interaction: its influence on protein synthesis and on growth rate.
(1993). Biochemical Society Transactions, vol. 21, ss. 851-857 -
A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome.
(1993). Journal of Bacteriology, vol. 175, ss. 240-250 -
Growth and translation elongation rate are sensitive to the concentration of EF-Tu.
(1993). Molecular Microbiology, vol. 8, ss. 761-770 DOI -
Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate.
(1993). Molecular Microbiology, vol. 7, ss. 275-284 DOI -
Comparison of the complete sequence of the str operon in Salmonella typhimurium and Escherichia coli.
(1992). Gene, vol. 120, ss. 93-98 DOI -
Missense substitutions lethal to essential functions of EF-Tu.
(1991). Biochimie, vol. 73, ss. 1457-1464 DOI -
Error-prone EF-Tu reduces in vivo enzyme activity and cellular growth rate.
(1991). Molecular Microbiology, vol. 5, ss. 623-630 -
The nucleotide sequence of rpsL and its flanking regions in Salmonella typhimurium.
(1991). Gene, vol. 104, ss. 123-124 DOI -
Mutant ribosomes can generate dominant kirromycin resistance.
(1991). Journal of Bacteriology, vol. 173, ss. 3635-3643 -
Both genes for EF-Tu in Salmonella typhimurium are individually dispensible for growth.
(1990). Journal of Molecular Biology, vol. 215, ss. 41-51 DOI -
Overproduction of release factor reduces spontaneous frameshifting and frameshift suppression by mutant elongation factor Tu.
(1990). Journal of Bacteriology, vol. 172, ss. 6721-6726 -
The role of EF-Tu and other translation components in determining translocation step size.
(1990). Biochimica et Biophysica Acta, Gene Structure and Expression, vol. 1050, ss. 274-278 DOI -
Resistance to fusidic acid can be linked to the Small Colony Variant (SCV) phenotype in Staphylococcus aureus.