Publikationer
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The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma.
(2022). Journal of Cellular Physiology, . vol. 237, ss. 743-762 DOI -
Mast cell chymase has a negative impact on human osteoblasts.
(2022). Matrix Biology, . vol. 112, ss. 1-19 DOI -
Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity..
(2022). Scientific Reports, vol. 12, ss. 21113- DOI -
Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action.
(2022). SIGNAL TRANSDUCTION AND TARGETED THERAPY, . vol. 7 DOI -
Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells.
(2022). Cell Death and Disease, . vol. 13 DOI -
TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition.
(2022). Molecular Oncology, . vol. 16, ss. 2330-2354 DOI -
The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma.
(2021). Cell Death and Disease, . vol. 12 DOI -
BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells.
(2021). Cellular Signalling, . vol. 87 DOI -
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling.
(2021). Oncogene, . vol. 40, ss. 3748-3765 DOI -
BMP signaling is a therapeutic target in ovarian cancer.
(2020). Cell Death Discovery, vol. 6 DOI -
TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness.
(2020). Oncogene, . vol. 39, ss. 4436-4449 DOI -
Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells.
(2019). Cellular Signalling, . vol. 54, ss. 122-129 DOI -
Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer.
(2019). Matrix Biology, vol. 80, ss. 29-45 DOI -
Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.
(2019). Journal of Biological Chemistry, vol. 294, ss. 4119-4136 DOI -
LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation.
(2019). Oncogenesis, vol. 8 DOI -
The TGFB2-AS1 lncRNA Regulates TGF-beta Signaling by Modulating Corepressor Activity.
(2019). Cell reports, . vol. 28, ss. 3182-3198.E11 DOI -
The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity.
(2019). Cell reports, . vol. 28, ss. 3182-3198.e11 DOI -
JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses.
(2019). CELLS, . vol. 8 DOI -
TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells.
(2019). The FASEB Journal, vol. 33, ss. 7822-7832 DOI -
Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.
(2018). Cell Death and Differentiation, vol. 25, ss. 885-903 DOI -
Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling.
(2018). Matrix Biology, . vol. 74, ss. 35-51 DOI -
Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells.
(2018). Oncogene, vol. 37, ss. 2515-2531 DOI -
Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases.
(2018). Scientific Reports, vol. 8 DOI -
TGF-beta Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition.
(2018). Cold Spring Harbor Perspectives in Biology, . vol. 10 DOI -
TGF-beta Family Signaling in Ductal Differentiation and Branching Morphogenesis.
(2018). Cold Spring Harbor Perspectives in Biology, . vol. 10 DOI -
Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells.
(2018). Journal of Cellular Physiology, vol. 233, ss. 7113-7127 DOI -
Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells.
(2018). Molecular Oncology, . vol. 12, ss. 1153-1174 DOI -
The protein kinase SIK downregulates the polarity protein Par3.
(2018). OncoTarget, vol. 9, ss. 5716-5735 DOI -
Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells.
(2017). International journal of experimental pathology (Print), vol. 98, ss. A10-A11 -
Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells.
(2017). FEBS Open Bio, vol. 7, ss. 405-413 DOI -
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
(2017). Molecular Cell, vol. 68, ss. 847-859.e7 DOI -
Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.
(2017). Cancer Research, vol. 77, ss. 1730-1740 DOI -
Epithelial-mesenchymal transition in cancer.
(2017). Molecular Oncology, . vol. 11, ss. 715-717 DOI -
TGF beta and the nuclear receptor LXR alpha crosstalk on lipid metabolism and epithelial to mesenchymal transition in hepatocellular carcinoma.
(2016). European Journal of Clinical Investigation, vol. 46, ss. 36-36 -
Single Chain Antibodies as Tools to Study transforming growth factor--Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens.
(2016). Molecular & Cellular Proteomics, vol. 15, ss. 1848-1856 DOI -
Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF- Signaling.
(2016). Journal of Cellular Biochemistry, vol. 117, ss. 938-945 DOI -
Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.
(2016). Scientific Reports, vol. 6 DOI -
Signaling Receptors for TGF-beta Family Members.
(2016). Cold Spring Harbor Perspectives in Biology, vol. 8 DOI -
In vitro and ex vivo vanadium antitumor activity in (TGF-beta)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients.
(2016). International Journal of Biochemistry and Cell Biology, vol. 74, ss. 121-134 DOI -
The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
(2016). OncoTarget, vol. 7, ss. 1120-1143 DOI -
Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.
(2016). I Feng, XH ; Xu, P ; Lin, X (red.) TGF-Beta Signaling, . ss. 147-181 DOI -
Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program.
(2016). Science Signaling, vol. 9 DOI -
Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.
(2016). Journal of Biological Chemistry, vol. 291, ss. 12706-12723 DOI -
Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.
(2015). Matrix Biology, vol. 43, ss. 42-60 DOI -
Tamoxifen Inhibits TGF-beta-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.
(2015). Journal of Cellular Physiology, vol. 230, ss. 3084-3092 DOI -
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures.
(2015). Nature Communications, vol. 6 DOI -
Transforming growth factor beta and bone morphogenetic protein actions in cancer progression.
(2015). The FEBS Journal, vol. 282, ss. 35-35 -
The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-beta signaling apparatus.
(2015). Science Signaling, vol. 8 DOI -
Targeting Tgf-Beta I With The Transforming Growth Factor Receptor Type I Kinase Inhibitor, Ly2157299, Modulates Stemness-Related Biomarkers In Hepatocellular Carcinoma.
(2015). Journal of Hepatology, vol. 62, ss. S429-S429 -
The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition.
(2015). Nucleic Acids Research, vol. 43, ss. 162-178 DOI -
Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling.
(2014). PLOS ONE, vol. 9, ss. e103651- DOI -
Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells.
(2014). Nucleic Acids Research, vol. 42, ss. 6921-6934 DOI -
Nucleosome regulatory dynamics in response to TGF beta.
(2014). Nucleic Acids Research, vol. 42, ss. 6921-6934 DOI -
Invasive cells follow Snail's slow and persistent pace.
(2014). Cell Cycle, vol. 13, ss. 2320-2321 DOI -
Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NF kappa B-Mediated Chemokine Production.
(2014). PLOS ONE, vol. 9, ss. e90921- DOI -
HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment.
(2013). Angiogenesis, vol. 16, ss. 889-902 DOI -
The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins.
(2013). Nucleic Acids Research, vol. 41, ss. 2950-2962 DOI -
Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells.
(2013). PLOS ONE, vol. 8, ss. e78157- DOI -
Coordination of TGF-beta Signaling by Ubiquitylation.
(2013). Molecular Cell, vol. 51, ss. 555-556 DOI -
TGF-beta in Human Disease.
DOI -
p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.
(2013). Journal of Cellular Physiology, vol. 228, ss. 801-813 DOI -
Context-dependent action of transforming growth factor β family members on normal and cancer stem cells.
(2012). Current pharmaceutical design, vol. 18, ss. 4072-4086 DOI -
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
(2012). Journal of Biological Chemistry, vol. 287, ss. 12867-12878 DOI -
Induction of epithelial-mesenchymal transition by transforming growth factor β.
(2012). Seminars in Cancer Biology, vol. 22, ss. 446-454 DOI -
Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition.
(2012). Oncogene, vol. 31, ss. 2862-2875 DOI -
Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition.
(2012). Journal of Biological Chemistry, vol. 287, ss. 7134-7145 DOI -
Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase.
(2012). Molecular & Cellular Proteomics, . vol. 11 DOI -
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).
(2011). Journal of Biological Chemistry, vol. 286, ss. 42349-42359 DOI -
Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: A useful in vitro model for testing new treatments.
(2011). British Journal of Dermatology, . vol. 164, ss. 263-272 DOI -
Regulation of Myosin Light Chain Function by BMP Signaling Controls Actin Cytoskeleton Remodeling.
(2011). Cellular Physiology and Biochemistry, vol. 28, ss. 1031-1044 DOI -
Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.
(2011). Journal of Biological Chemistry, vol. 286, ss. 341-353 DOI -
TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2.
(2011). Cellular Physiology and Biochemistry, Basel: Karger. vol. 28, ss. 229-238 DOI -
Role of TGF-β signaling in EMT, cancer progression and metastasis.
(2011). Drug Discovery Today , . vol. 8, ss. 121-126 DOI -
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.
(2011). Journal of Cell Biology, vol. 195, ss. 1123-1140 DOI -
The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma..
(2011). PLOS ONE, vol. 6, ss. e23057- DOI -
TGF beta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death.
(2011). Journal of Biological Chemistry, vol. 286, ss. 5003-5011 DOI -
Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle Cells.
(2011). Journal of Biological Chemistry, vol. 286, ss. 7917-7924 DOI -
Quantitative analysis of transient and sustained transforming growth factor-beta signaling dynamics.
(2011). Molecular Systems Biology, . vol. 7 DOI -
Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
(2010). Journal of Biological Chemistry, USA: The American Society for Biochemistry and Molecular Biology, Inc.. vol. 285, ss. 19727-19737 DOI -
Immortalized keratinocytes from Epidermolytic Ichthyosis-patients reproduce the disease phenotype in vitro.
(2010). Journal of Investigative Dermatology, vol. 130, ss. S83-S83 -
The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.
(2010). Journal of Biological Chemistry, USA: The American Society for Biochemistry and Molecular Biology, Inc.. vol. 285, ss. 23647-23654 DOI -
PARP-1 attenuates Smad-mediated transcription.
(2010). Molecular Cell, vol. 40, ss. 521-532 DOI -
Integrins open the way to epithelial-mesenchymal transitions: Comment on: Bianchi A, et al. Cell Cycle 2010; 9:1647–59.
(2010). Cell Cycle, . vol. 9, ss. 1682-1682 DOI -
Proteomic identification of CD44 interacting proteins.
(2010). IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, vol. 62, ss. 833-840 DOI -
Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition.
(2009). Journal of dermatological science (Amsterdam), . vol. 53, ss. 198-206 DOI -
Growth factor regulation of hyaluronan deposition in malignancies..
(2009). I Robert Stern (red.) Hyaluronan in Cancer Biology., San Diego, Calif.: Elsevier Inc.. ss. 37-50 DOI -
Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom.
(2009). BMC Evolutionary Biology, . vol. 9, ss. 28- DOI -
Epithelial-mesenchymal transition as a mechanism of metastasis.
(2009). I Keshamouni, V., Arenberg, D., Kalemkerian, G. (red.) Lung Cancer Metastasis, . ss. 65-92 DOI -
A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF‑β mediated epithelial–mesenchymal transition.
(2009). Nature Cell Biology, vol. 11, ss. 943-950 DOI -
Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.
(2008). Oncogene, vol. 27, ss. 1218-1230 DOI -
Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis.
(2008). Connective Tissue Research, vol. 49, ss. 215-218 DOI -
TGFβ induces SIK to negatively regulate type I receptor kinase signaling.
(2008). Journal of Cell Biology, . vol. 182, ss. 655-662 DOI -
Cancer-associated fibroblasts and the role of TGFbeta.
(2008). I Jakowlew, Sonia B. (red.) Transforming Growth Factor-beta in Cancer Therapy, Vol II, Totowa, NJ: The Humana Press, Inc.. ss. 417-441 DOI -
TGF-beta Targets PAX3 to Control Melanocyte Differentiation.
(2008). Developmental Cell, vol. 15, ss. 797-799 DOI -
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition.
(2008). Journal of Biological Chemistry, vol. 283, ss. 33437-33446 DOI -
TGF-beta and Smad signaling in transcriptome reprogramming during EMT.
(2008). I Sonia B. Jakowlew (red.) Transforming Growth Factor-Beta in Cancer Therapy Totowa, NJ: The Human Press Inc.. -
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.
(2007). Biochemical Journal, vol. 404, ss. 327-336 DOI -
Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells.
(2007). International Journal of Cancer, vol. 120, ss. 2557-2567 DOI -
Notch signaling is necessary for epithelial growth arrest by TGF-beta.
(2007). Journal of Cell Biology, vol. 176, ss. 695-707 DOI -
Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.
(2007). Molecular Oncology, vol. 1, ss. 55-71 DOI